Microglia-independent rAAV-induced inflammation causes persistent ocular immune dysregulation rescued by S1P receptor modulation.

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Title: Microglia-independent rAAV-induced inflammation causes persistent ocular immune dysregulation rescued by S1P receptor modulation.
Authors: Langer PM; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA., Clare AJ; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK., Peng X; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA., Costello KL; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA., Cendanawati S; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK., Wilson LL; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA., Ward A; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK., Bell OH; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK., Chu CJ; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; Institute of Ophthalmology, University College London, London EC1V 9EL, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK., Chan YK; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA., Dick AD; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK; Institute of Ophthalmology, University College London, London EC1V 9EL, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK., Pepple KL; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA. Electronic address: kpepple@uw.edu., Copland DA; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK. Electronic address: dave.copland@bristol.ac.uk.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 May 06; Vol. 34 (5), pp. 2840-2862. Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-0024
DOI:10.1016/j.ymthe.2026.02.018