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Microglia-independent rAAV-induced inflammation causes persistent ocular immune dysregulation rescued by S1P receptor modulation.

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Title: Microglia-independent rAAV-induced inflammation causes persistent ocular immune dysregulation rescued by S1P receptor modulation.
Authors: Langer PM; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA., Clare AJ; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK., Peng X; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA., Costello KL; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA., Cendanawati S; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK., Wilson LL; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA., Ward A; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK., Bell OH; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK., Chu CJ; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; Institute of Ophthalmology, University College London, London EC1V 9EL, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK., Chan YK; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA., Dick AD; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK; Institute of Ophthalmology, University College London, London EC1V 9EL, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK., Pepple KL; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA. Electronic address: kpepple@uw.edu., Copland DA; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK. Electronic address: dave.copland@bristol.ac.uk.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 May 06; Vol. 34 (5), pp. 2840-2862. Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Microglia-independent rAAV-induced inflammation causes persistent ocular immune dysregulation rescued by S1P receptor modulation.
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  Data: <searchLink fieldCode="AU" term="%22Langer+PM%22">Langer PM</searchLink>; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA.<br /><searchLink fieldCode="AU" term="%22Clare+AJ%22">Clare AJ</searchLink>; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK.<br /><searchLink fieldCode="AU" term="%22Peng+X%22">Peng X</searchLink>; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA.<br /><searchLink fieldCode="AU" term="%22Costello+KL%22">Costello KL</searchLink>; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA.<br /><searchLink fieldCode="AU" term="%22Cendanawati+S%22">Cendanawati S</searchLink>; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Wilson+LL%22">Wilson LL</searchLink>; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA.<br /><searchLink fieldCode="AU" term="%22Ward+A%22">Ward A</searchLink>; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Bell+OH%22">Bell OH</searchLink>; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Chu+CJ%22">Chu CJ</searchLink>; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; Institute of Ophthalmology, University College London, London EC1V 9EL, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK.<br /><searchLink fieldCode="AU" term="%22Chan+YK%22">Chan YK</searchLink>; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Dick+AD%22">Dick AD</searchLink>; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK; Institute of Ophthalmology, University College London, London EC1V 9EL, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK.<br /><searchLink fieldCode="AU" term="%22Pepple+KL%22">Pepple KL</searchLink>; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA. Electronic address: kpepple@uw.edu.<br /><searchLink fieldCode="AU" term="%22Copland+DA%22">Copland DA</searchLink>; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK. Electronic address: dave.copland@bristol.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22100890581%22">Molecular therapy : the journal of the American Society of Gene Therapy</searchLink> [Mol Ther] 2026 May 06; Vol. 34 (5), pp. 2840-2862. <i>Date of Electronic Publication: </i>2026 Mar 13.
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