Microfluidic nanomagnetically isolated neuron- and astrocyte-derived extracellular vesicles to differentiate Lewy body and Alzheimer's disease.

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Title: Microfluidic nanomagnetically isolated neuron- and astrocyte-derived extracellular vesicles to differentiate Lewy body and Alzheimer's disease.
Authors: Yang SJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA USA., Lin AA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Shen H; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA USA., Pappalardo LW; Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA USA., Spychalski GB; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Rosario J; Department of Biology, University of Pennsylvania, Philadelphia, PA USA., Forsberg LK; Department of Neurology, Mayo Clinic, Rochester, MN USA., Grant KM; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN USA., Buser JR; Consonant Systems, LLC, Philadelphia, PA USA., Savica R; Department of Neurology, Mayo Clinic, Rochester, MN USA., O'Bryant S; Health Science Center at Fort Worth, University of North Texas, Fort Worth, TX USA., Jones DT; Department of Neurology, Mayo Clinic, Rochester, MN USA., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL USA., Reichard RR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN USA., Nguyen AT; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN USA., Meaney DF; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA USA., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN USA., Ross OA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL USA., McLean PJ; Department of Neuroscience, Mayo Clinic, Jacksonville, FL USA., Issadore D; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA USA.
Source: Npj biosensing [NPJ Biosens] 2026; Vol. 3 (1), pp. 19. Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918900941706676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 3004-8656 (Electronic) Linking ISSN: 30048656 NLM ISO Abbreviation: NPJ Biosens Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:3004-8656
DOI:10.1038/s44328-026-00086-x