Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice.

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Title: Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice.
Authors: Korstanje R; The Jackson Laboratory, Bar Harbor, ME, 04609, USA. ron.korstanje@jax.org., Strong R; Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, and Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Salmon AB; Geriatric Research, Education and Clinical Center and Research Service, Department of Molecular Medicine, and Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Bogue MA; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Curran SP; Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA., Diaz V; Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, and Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Fernandez E; Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, and Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Ginsburg B; Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Han M; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109, USA., Harrison DE; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Kaczorowski C; Department of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA., Kaeberlein M; Optispan, Inc, Seattle, WA, 98168, USA., Kennedy BK; National University of Singapore, Singapore, Singapore., Kumar N; Division of Geriatric and Palliative Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., LaCroix-Fralish M; Cellular Longevity Inc, San Francisco, CA, USA., Leiser SF; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA., Nelson JF; Department of Cellular and Integrative Physiology and Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Polymenis M; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, 77843, USA., Reifsnyder PC; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Rosenthal NA; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Silva E; Cellular Longevity Inc, San Francisco, CA, USA., Tower J; Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA., Miller RA; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109, USA.
Source: GeroScience [Geroscience] 2026 Jun; Vol. 48 (3), pp. 3821-3830. Date of Electronic Publication: 2026 Mar 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2509-2723
DOI:10.1007/s11357-026-02201-2