Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice.
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| Title: | Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice. |
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| Authors: | Korstanje R; The Jackson Laboratory, Bar Harbor, ME, 04609, USA. ron.korstanje@jax.org., Strong R; Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, and Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Salmon AB; Geriatric Research, Education and Clinical Center and Research Service, Department of Molecular Medicine, and Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Bogue MA; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Curran SP; Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA., Diaz V; Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, and Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Fernandez E; Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, and Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Ginsburg B; Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Han M; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109, USA., Harrison DE; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Kaczorowski C; Department of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA., Kaeberlein M; Optispan, Inc, Seattle, WA, 98168, USA., Kennedy BK; National University of Singapore, Singapore, Singapore., Kumar N; Division of Geriatric and Palliative Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., LaCroix-Fralish M; Cellular Longevity Inc, San Francisco, CA, USA., Leiser SF; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA., Nelson JF; Department of Cellular and Integrative Physiology and Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Polymenis M; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, 77843, USA., Reifsnyder PC; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Rosenthal NA; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Silva E; Cellular Longevity Inc, San Francisco, CA, USA., Tower J; Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA., Miller RA; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109, USA. |
| Source: | GeroScience [Geroscience] 2026 Jun; Vol. 48 (3), pp. 3821-3830. Date of Electronic Publication: 2026 Mar 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41843349 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Korstanje+R%22">Korstanje R</searchLink>; The Jackson Laboratory, Bar Harbor, ME, 04609, USA. ron.korstanje@jax.org.<br /><searchLink fieldCode="AU" term="%22Strong+R%22">Strong R</searchLink>; Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, and Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Salmon+AB%22">Salmon AB</searchLink>; Geriatric Research, Education and Clinical Center and Research Service, Department of Molecular Medicine, and Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Bogue+MA%22">Bogue MA</searchLink>; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.<br /><searchLink fieldCode="AU" term="%22Curran+SP%22">Curran SP</searchLink>; Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.<br /><searchLink fieldCode="AU" term="%22Diaz+V%22">Diaz V</searchLink>; Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, and Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Fernandez+E%22">Fernandez E</searchLink>; Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, and Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Ginsburg+B%22">Ginsburg B</searchLink>; Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Han+M%22">Han M</searchLink>; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Harrison+DE%22">Harrison DE</searchLink>; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.<br /><searchLink fieldCode="AU" term="%22Kaczorowski+C%22">Kaczorowski C</searchLink>; Department of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Kaeberlein+M%22">Kaeberlein M</searchLink>; Optispan, Inc, Seattle, WA, 98168, USA.<br /><searchLink fieldCode="AU" term="%22Kennedy+BK%22">Kennedy BK</searchLink>; National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Kumar+N%22">Kumar N</searchLink>; Division of Geriatric and Palliative Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22LaCroix-Fralish+M%22">LaCroix-Fralish M</searchLink>; Cellular Longevity Inc, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Leiser+SF%22">Leiser SF</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+JF%22">Nelson JF</searchLink>; Department of Cellular and Integrative Physiology and Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Polymenis+M%22">Polymenis M</searchLink>; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, 77843, USA.<br /><searchLink fieldCode="AU" term="%22Reifsnyder+PC%22">Reifsnyder PC</searchLink>; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.<br /><searchLink fieldCode="AU" term="%22Rosenthal+NA%22">Rosenthal NA</searchLink>; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.<br /><searchLink fieldCode="AU" term="%22Silva+E%22">Silva E</searchLink>; Cellular Longevity Inc, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tower+J%22">Tower J</searchLink>; Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA.<br /><searchLink fieldCode="AU" term="%22Miller+RA%22">Miller RA</searchLink>; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101686284%22">GeroScience</searchLink> [Geroscience] 2026 Jun; Vol. 48 (3), pp. 3821-3830. <i>Date of Electronic Publication: </i>2026 Mar 17. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101686284 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2509-2723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225092723%22">25092723 </searchLink><i>NLM ISO Abbreviation: </i>Geroscience <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41843349 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s11357-026-02201-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 3821 Titles: – TitleFull: Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Korstanje R – PersonEntity: Name: NameFull: Strong R – PersonEntity: Name: NameFull: Salmon AB – PersonEntity: Name: NameFull: Bogue MA – PersonEntity: Name: NameFull: Curran SP – PersonEntity: Name: NameFull: Diaz V – PersonEntity: Name: NameFull: Fernandez E – PersonEntity: Name: NameFull: Ginsburg B – PersonEntity: Name: NameFull: Han M – PersonEntity: Name: NameFull: Harrison DE – PersonEntity: Name: NameFull: Kaczorowski C – PersonEntity: Name: NameFull: Kaeberlein M – PersonEntity: Name: NameFull: Kennedy BK – PersonEntity: Name: NameFull: Kumar N – PersonEntity: Name: NameFull: LaCroix-Fralish M – PersonEntity: Name: NameFull: Leiser SF – PersonEntity: Name: NameFull: Nelson JF – PersonEntity: Name: NameFull: Polymenis M – PersonEntity: Name: NameFull: Reifsnyder PC – PersonEntity: Name: NameFull: Rosenthal NA – PersonEntity: Name: NameFull: Silva E – PersonEntity: Name: NameFull: Tower J – PersonEntity: Name: NameFull: Miller RA IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2026 Jun Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2509-2723 Numbering: – Type: volume Value: 48 – Type: issue Value: 3 Titles: – TitleFull: GeroScience Type: main |
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