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Fine-tuning ERK activity enables proliferation-differentiation balance during lineage specification of human embryonic stem cells.

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Title: Fine-tuning ERK activity enables proliferation-differentiation balance during lineage specification of human embryonic stem cells.
Authors: Ma C; Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, and School of Medicine, Zhejiang University, Hangzhou, China.; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China., Meng W; Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, and School of Medicine, Zhejiang University, Hangzhou, China.; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China., Huang J; Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China.; School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China., Zheng W; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.; Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Xu X; Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, and School of Medicine, Zhejiang University, Hangzhou, China.; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China., Cheng T; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.; Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Li Z; Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, and School of Medicine, Zhejiang University, Hangzhou, China.; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China., Liu Y; Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, and School of Medicine, Zhejiang University, Hangzhou, China.; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China., Shen H; Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, and School of Medicine, Zhejiang University, Hangzhou, China.; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China., He F; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.; Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Esposito A; Centre for Genome Engineering and Maintenance, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, United Kingdom., Xu P; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.; Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Venkitaraman A; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore, Singapore., Ma J; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.; Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Xu H; Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China.; School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China., Liang H; Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, and School of Medicine, Zhejiang University, Hangzhou, China.; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.
Source: PLoS biology [PLoS Biol] 2026 Mar 17; Vol. 24 (3), pp. e3003711. Date of Electronic Publication: 2026 Mar 17 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Fine-tuning ERK activity enables proliferation-differentiation balance during lineage specification of human embryonic stem cells.
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  Data: <searchLink fieldCode="AU" term="%22Ma+C%22">Ma C</searchLink>; Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, and School of Medicine, Zhejiang University, Hangzhou, China.; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Meng+W%22">Meng W</searchLink>; Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, and School of Medicine, Zhejiang University, Hangzhou, China.; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China.; School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zheng+W%22">Zheng W</searchLink>; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.; Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, and School of Medicine, Zhejiang University, Hangzhou, China.; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Cheng+T%22">Cheng T</searchLink>; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.; Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, and School of Medicine, Zhejiang University, Hangzhou, China.; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, and School of Medicine, Zhejiang University, Hangzhou, China.; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Shen+H%22">Shen H</searchLink>; Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, and School of Medicine, Zhejiang University, Hangzhou, China.; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22He+F%22">He F</searchLink>; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.; Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Esposito+A%22">Esposito A</searchLink>; Centre for Genome Engineering and Maintenance, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Xu+P%22">Xu P</searchLink>; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.; Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Venkitaraman+A%22">Venkitaraman A</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.; Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China.; School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liang+H%22">Liang H</searchLink>; Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, and School of Medicine, Zhejiang University, Hangzhou, China.; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China.
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  Data: <searchLink fieldCode="JN" term="%22101183755%22">PLoS biology</searchLink> [PLoS Biol] 2026 Mar 17; Vol. 24 (3), pp. e3003711. <i>Date of Electronic Publication: </i>2026 Mar 17 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101183755 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1545-7885 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215449173%22">15449173 </searchLink><i>NLM ISO Abbreviation: </i>PLoS Biol <i>Subsets: </i>MEDLINE
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        Value: 10.1371/journal.pbio.3003711
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              Text: 2026 Mar 17
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