Microglial fructose metabolism is essential for glioblastoma growth.

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Title: Microglial fructose metabolism is essential for glioblastoma growth.
Authors: Billingham LK; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., DeLay SL; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Eshac Y; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Chia TY; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Tripathi S; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Olson IE; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Zilinger K; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Subbiah J; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Wang Z; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Immunology and Microbial Pathogenesis Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065., Sadagopan NS; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Najem H; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Cognet G; Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637., Katz JL; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Du R; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Nandoliya KR; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Boland LK; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Ignacio Vázquez-Cervantes G; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Wang S; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Wan H; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Lipshutz AB; Immunology and Microbial Pathogenesis Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065., Murphy AR; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Duffy J; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Balyasnikova IV; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Zhang P; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Heiland DH; Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg 79106, Germany.; German Cancer Consortium (Deutsches Konsortium für Translationale Krebsforschung), partner site Freiburg, Freiburg 69120, Germany.; Department of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen Nuremberg, Erlangen 91054, Germany.; Translational Neurosurgery, Friedrich-Alexander University Erlangen Nuremberg, Erlangen 91054, Germany., Ahmed AU; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Lee-Chang C; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Heimberger AB; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Perry JSA; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Immunology and Microbial Pathogenesis Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Muir A; Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637., Chandel NS; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60657., Miska J; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Mar 24; Vol. 123 (12), pp. e2521256123. Date of Electronic Publication: 2026 Mar 17.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2521256123