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IRX4204 sensitizes multiple myeloma to ferroptosis and improves lenalidomide efficacy through the HMOX1-GPX4 axis.

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Title: IRX4204 sensitizes multiple myeloma to ferroptosis and improves lenalidomide efficacy through the HMOX1-GPX4 axis.
Authors: Wu J; Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA., Yan Z; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA., Burcher K; Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA., Han Z; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA., Nikiforov MA; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA., Vuligonda V; Io Therapeutics, Inc, Spring, TX, 77387, USA., Sanders M; Io Therapeutics, Inc, Spring, TX, 77387, USA., Kang Y; Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA. yubin.kang@duke.edu.
Source: Scientific reports [Sci Rep] 2026 Mar 17; Vol. 16 (1). Date of Electronic Publication: 2026 Mar 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: IRX4204 sensitizes multiple myeloma to ferroptosis and improves lenalidomide efficacy through the HMOX1-GPX4 axis.
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  Data: <searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Yan+Z%22">Yan Z</searchLink>; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Burcher+K%22">Burcher K</searchLink>; Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Han+Z%22">Han Z</searchLink>; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Nikiforov+MA%22">Nikiforov MA</searchLink>; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA.<br /><searchLink fieldCode="AU" term="%22Vuligonda+V%22">Vuligonda V</searchLink>; Io Therapeutics, Inc, Spring, TX, 77387, USA.<br /><searchLink fieldCode="AU" term="%22Sanders+M%22">Sanders M</searchLink>; Io Therapeutics, Inc, Spring, TX, 77387, USA.<br /><searchLink fieldCode="AU" term="%22Kang+Y%22">Kang Y</searchLink>; Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA. yubin.kang@duke.edu.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Mar 17; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 Mar 17.
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        Value: 10.1038/s41598-026-42123-9
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      – TitleFull: IRX4204 sensitizes multiple myeloma to ferroptosis and improves lenalidomide efficacy through the HMOX1-GPX4 axis.
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              Text: 2026 Mar 17
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