A narrative review on trazodone as a multimodal and multifunctional antidepressant: clinical relevance of formulations, dosing, and pharmacokinetic/pharmacodynamic targets.

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Title: A narrative review on trazodone as a multimodal and multifunctional antidepressant: clinical relevance of formulations, dosing, and pharmacokinetic/pharmacodynamic targets.
Authors: Cuomo A; Division of Psychiatry, Department of Molecular Medicine, University of Siena School of Medicine, Viale Bracci 16, Siena, 53100, Italy. alessandrocuomo86@gmail.com., Pompili M; Faculty of Medicine and Psychology, Department of Neurosciences, Mental Health and Sensory Organs, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy., Vita A; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Spina E; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Caraci F; Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.; Department of Drug and Health Sciences, University of Catania, Catania, Italy.; Oasi Research Institute - IRCCS, Unit of Neuropharmacology and Translational Neurosciences, Troina, Italy., Fagiolini A; Division of Psychiatry, Department of Molecular Medicine, University of Siena School of Medicine, Viale Bracci 16, Siena, 53100, Italy.
Source: Annals of general psychiatry [Ann Gen Psychiatry] 2026 Mar 18; Vol. 25 (1). Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101236515 Publication Model: Electronic Cited Medium: Print ISSN: 1744-859X (Print) Linking ISSN: 1744859X NLM ISO Abbreviation: Ann Gen Psychiatry Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1744-859X
DOI:10.1186/s12991-026-00643-8