A narrative review on trazodone as a multimodal and multifunctional antidepressant: clinical relevance of formulations, dosing, and pharmacokinetic/pharmacodynamic targets.
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| Title: | A narrative review on trazodone as a multimodal and multifunctional antidepressant: clinical relevance of formulations, dosing, and pharmacokinetic/pharmacodynamic targets. |
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| Authors: | Cuomo A; Division of Psychiatry, Department of Molecular Medicine, University of Siena School of Medicine, Viale Bracci 16, Siena, 53100, Italy. alessandrocuomo86@gmail.com., Pompili M; Faculty of Medicine and Psychology, Department of Neurosciences, Mental Health and Sensory Organs, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy., Vita A; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Spina E; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Caraci F; Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.; Department of Drug and Health Sciences, University of Catania, Catania, Italy.; Oasi Research Institute - IRCCS, Unit of Neuropharmacology and Translational Neurosciences, Troina, Italy., Fagiolini A; Division of Psychiatry, Department of Molecular Medicine, University of Siena School of Medicine, Viale Bracci 16, Siena, 53100, Italy. |
| Source: | Annals of general psychiatry [Ann Gen Psychiatry] 2026 Mar 18; Vol. 25 (1). Date of Electronic Publication: 2026 Mar 18. |
| Publication Type: | Journal Article; Review |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101236515 Publication Model: Electronic Cited Medium: Print ISSN: 1744-859X (Print) Linking ISSN: 1744859X NLM ISO Abbreviation: Ann Gen Psychiatry Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41845402 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A narrative review on trazodone as a multimodal and multifunctional antidepressant: clinical relevance of formulations, dosing, and pharmacokinetic/pharmacodynamic targets. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Cuomo+A%22">Cuomo A</searchLink>; Division of Psychiatry, Department of Molecular Medicine, University of Siena School of Medicine, Viale Bracci 16, Siena, 53100, Italy. alessandrocuomo86@gmail.com.<br /><searchLink fieldCode="AU" term="%22Pompili+M%22">Pompili M</searchLink>; Faculty of Medicine and Psychology, Department of Neurosciences, Mental Health and Sensory Organs, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Vita+A%22">Vita A</searchLink>; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Spina+E%22">Spina E</searchLink>; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Caraci+F%22">Caraci F</searchLink>; Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.; Department of Drug and Health Sciences, University of Catania, Catania, Italy.; Oasi Research Institute - IRCCS, Unit of Neuropharmacology and Translational Neurosciences, Troina, Italy.<br /><searchLink fieldCode="AU" term="%22Fagiolini+A%22">Fagiolini A</searchLink>; Division of Psychiatry, Department of Molecular Medicine, University of Siena School of Medicine, Viale Bracci 16, Siena, 53100, Italy. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101236515%22">Annals of general psychiatry</searchLink> [Ann Gen Psychiatry] 2026 Mar 18; Vol. 25 (1). <i>Date of Electronic Publication: </i>2026 Mar 18. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Review – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101236515 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>1744-859X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221744859X%22">1744859X </searchLink><i>NLM ISO Abbreviation: </i>Ann Gen Psychiatry <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41845402 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s12991-026-00643-8 Languages: – Code: eng Text: English Titles: – TitleFull: A narrative review on trazodone as a multimodal and multifunctional antidepressant: clinical relevance of formulations, dosing, and pharmacokinetic/pharmacodynamic targets. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Cuomo A – PersonEntity: Name: NameFull: Pompili M – PersonEntity: Name: NameFull: Vita A – PersonEntity: Name: NameFull: Spina E – PersonEntity: Name: NameFull: Caraci F – PersonEntity: Name: NameFull: Fagiolini A IsPartOfRelationships: – BibEntity: Dates: – D: 18 M: 03 Text: 2026 Mar 18 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 1744-859X Numbering: – Type: volume Value: 25 – Type: issue Value: 1 Titles: – TitleFull: Annals of general psychiatry Type: main |
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