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Discovery of Triazine-Based Toll-Like Receptor 9 Antagonists with Oral Activity.

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Title: Discovery of Triazine-Based Toll-Like Receptor 9 Antagonists with Oral Activity.
Authors: Mandler MD; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Zhu Y; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Hollenbeck EC; Bristol Myers Squibb Research, Brisbane, California 94005, United States., Ziegler M; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Posy SL; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Mukundan S; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Halpern OS; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Driscoll JP; Bristol Myers Squibb Research, Brisbane, California 94005, United States., Wang T; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Huang L; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Fernando G; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Jung H; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Li L; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Cutrone J; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Baswar D; Biocon Bristol Myers Squibb R&D Centre, Bangalore 560100, India., Eapen P; Biocon Bristol Myers Squibb R&D Centre, Bangalore 560100, India., Traeger SC; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Srivastava S; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Olsen J; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Everlof GG; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Trujillo G; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Ellsworth BA; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States., Regueiro-Ren A; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2026 Feb 27; Vol. 17 (3), pp. 727-732. Date of Electronic Publication: 2026 Feb 27 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
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  Data: Discovery of Triazine-Based Toll-Like Receptor 9 Antagonists with Oral Activity.
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  Data: <searchLink fieldCode="AU" term="%22Mandler+MD%22">Mandler MD</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Hollenbeck+EC%22">Hollenbeck EC</searchLink>; Bristol Myers Squibb Research, Brisbane, California 94005, United States.<br /><searchLink fieldCode="AU" term="%22Ziegler+M%22">Ziegler M</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Posy+SL%22">Posy SL</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Mukundan+S%22">Mukundan S</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Halpern+OS%22">Halpern OS</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Driscoll+JP%22">Driscoll JP</searchLink>; Bristol Myers Squibb Research, Brisbane, California 94005, United States.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Huang+L%22">Huang L</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Fernando+G%22">Fernando G</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Jung+H%22">Jung H</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Cutrone+J%22">Cutrone J</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Baswar+D%22">Baswar D</searchLink>; Biocon Bristol Myers Squibb R&D Centre, Bangalore 560100, India.<br /><searchLink fieldCode="AU" term="%22Eapen+P%22">Eapen P</searchLink>; Biocon Bristol Myers Squibb R&D Centre, Bangalore 560100, India.<br /><searchLink fieldCode="AU" term="%22Traeger+SC%22">Traeger SC</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Srivastava+S%22">Srivastava S</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Olsen+J%22">Olsen J</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Everlof+GG%22">Everlof GG</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Trujillo+G%22">Trujillo G</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Ellsworth+BA%22">Ellsworth BA</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Regueiro-Ren+A%22">Regueiro-Ren A</searchLink>; Bristol Myers Squibb Research, Princeton, New Jersey 08543, United States.
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2026 Feb 27; Vol. 17 (3), pp. 727-732. <i>Date of Electronic Publication: </i>2026 Feb 27 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101521073 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1948-5875 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219485875%22">19485875 </searchLink><i>NLM ISO Abbreviation: </i>ACS Med Chem Lett <i>Subsets: </i>PubMed not MEDLINE
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