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Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans.

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Title: Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans.
Authors: Langer HT; Department of Geriatrics and Medical Gerontology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. Electronic address: henning-tim.langer@charite.de., Gilmore NK; Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA, USA., Hayden CMT; Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA, USA., Roux J; Biomeostasis, Marseille, France., Bariohay B; Biomeostasis, Marseille, France., Rouquet T; Biomeostasis, Marseille, France., Awada M; Biomeostasis, Marseille, France., Marcotorchino J; Biomeostasis, Marseille, France., Bournot L; Biomeostasis, Marseille, France., Nunn E; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Titchenell PM; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Liskiewicz D; Institute for Diabetes and Obesity, Helmholtz Munich, German Center for Diabetes Research (DZD) and Walther Straub Institute for Pharmacology and Toxicology, Ludwig-Maximilians University Munich, Munich, Germany., Müller TD; Institute for Diabetes and Obesity, Helmholtz Munich, German Center for Diabetes Research (DZD) and Walther Straub Institute for Pharmacology and Toxicology, Ludwig-Maximilians University Munich, Munich, Germany., Anyiam O; Centre of Metabolism, Ageing & Physiology, MRC/Versus Arthritis Centre of Excellence for Musculoskeletal Research, NIHR Biomedical Research Centre (BRC), University of Nottingham, Royal Derby Hospital Medical School, Derby, UK., Atherton PJ; Centre of Metabolism, Ageing & Physiology, MRC/Versus Arthritis Centre of Excellence for Musculoskeletal Research, NIHR Biomedical Research Centre (BRC), University of Nottingham, Royal Derby Hospital Medical School, Derby, UK; Faculty of Sport and Health Science, Ritsumeikan Advanced Research Academy (RARA), Ritsumeikan University, Kyoto, Japan., Idris I; Centre of Metabolism, Ageing & Physiology, MRC/Versus Arthritis Centre of Excellence for Musculoskeletal Research, NIHR Biomedical Research Centre (BRC), University of Nottingham, Royal Derby Hospital Medical School, Derby, UK., Hentschel A; Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany., Roos A; Department of Neuropediatrics and Neuromuscular Centre for Children and Adolescents, University Hospital Essen, Duisburg-Essen University, Essen, Germany; Brain and Mind Research Institute, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada., Haritonow N; Department of Geriatrics and Medical Gerontology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Norman K; Department of Geriatrics and Medical Gerontology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam Rehbrücke, Nuthetal, Germany., Müller-Werdan U; Department of Geriatrics and Medical Gerontology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Baar K; Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA, USA; Department of Physiology and Membrane Biology, University of California, Davis Health, Davis, CA, USA.
Source: Cell reports. Medicine [Cell Rep Med] 2026 Mar 17; Vol. 7 (3), pp. 102665.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans.
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  Data: <searchLink fieldCode="AU" term="%22Langer+HT%22">Langer HT</searchLink>; Department of Geriatrics and Medical Gerontology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. Electronic address: henning-tim.langer@charite.de.<br /><searchLink fieldCode="AU" term="%22Gilmore+NK%22">Gilmore NK</searchLink>; Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hayden+CMT%22">Hayden CMT</searchLink>; Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Roux+J%22">Roux J</searchLink>; Biomeostasis, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Bariohay+B%22">Bariohay B</searchLink>; Biomeostasis, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Rouquet+T%22">Rouquet T</searchLink>; Biomeostasis, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Awada+M%22">Awada M</searchLink>; Biomeostasis, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Marcotorchino+J%22">Marcotorchino J</searchLink>; Biomeostasis, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Bournot+L%22">Bournot L</searchLink>; Biomeostasis, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Nunn+E%22">Nunn E</searchLink>; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Titchenell+PM%22">Titchenell PM</searchLink>; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Liskiewicz+D%22">Liskiewicz D</searchLink>; Institute for Diabetes and Obesity, Helmholtz Munich, German Center for Diabetes Research (DZD) and Walther Straub Institute for Pharmacology and Toxicology, Ludwig-Maximilians University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+TD%22">Müller TD</searchLink>; Institute for Diabetes and Obesity, Helmholtz Munich, German Center for Diabetes Research (DZD) and Walther Straub Institute for Pharmacology and Toxicology, Ludwig-Maximilians University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Anyiam+O%22">Anyiam O</searchLink>; Centre of Metabolism, Ageing & Physiology, MRC/Versus Arthritis Centre of Excellence for Musculoskeletal Research, NIHR Biomedical Research Centre (BRC), University of Nottingham, Royal Derby Hospital Medical School, Derby, UK.<br /><searchLink fieldCode="AU" term="%22Atherton+PJ%22">Atherton PJ</searchLink>; Centre of Metabolism, Ageing & Physiology, MRC/Versus Arthritis Centre of Excellence for Musculoskeletal Research, NIHR Biomedical Research Centre (BRC), University of Nottingham, Royal Derby Hospital Medical School, Derby, UK; Faculty of Sport and Health Science, Ritsumeikan Advanced Research Academy (RARA), Ritsumeikan University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Idris+I%22">Idris I</searchLink>; Centre of Metabolism, Ageing & Physiology, MRC/Versus Arthritis Centre of Excellence for Musculoskeletal Research, NIHR Biomedical Research Centre (BRC), University of Nottingham, Royal Derby Hospital Medical School, Derby, UK.<br /><searchLink fieldCode="AU" term="%22Hentschel+A%22">Hentschel A</searchLink>; Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Roos+A%22">Roos A</searchLink>; Department of Neuropediatrics and Neuromuscular Centre for Children and Adolescents, University Hospital Essen, Duisburg-Essen University, Essen, Germany; Brain and Mind Research Institute, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada.<br /><searchLink fieldCode="AU" term="%22Haritonow+N%22">Haritonow N</searchLink>; Department of Geriatrics and Medical Gerontology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Norman+K%22">Norman K</searchLink>; Department of Geriatrics and Medical Gerontology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam Rehbrücke, Nuthetal, Germany.<br /><searchLink fieldCode="AU" term="%22Müller-Werdan+U%22">Müller-Werdan U</searchLink>; Department of Geriatrics and Medical Gerontology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Baar+K%22">Baar K</searchLink>; Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA, USA; Department of Physiology and Membrane Biology, University of California, Davis Health, Davis, CA, USA.
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