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The AICL-KLRF1 axis supports CD4-CD8 T cell communication and cytokine competence in pre-exhausted CD8+ T cells.

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Title: The AICL-KLRF1 axis supports CD4-CD8 T cell communication and cytokine competence in pre-exhausted CD8+ T cells.
Authors: Barone M; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany., Peidli S; Institute of Pathology, Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.; Institute of Biology, Humbolt-Universität zu Berlin, Berlin, Germany., Neuschulz A; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany., Riesterer K; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany., Iwert C; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany., Junquera L; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany., Sai S; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Bolaji O; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany., Bakoueva D; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany., Appelt C; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany., Obermayer B; Core Unit Bioinformatics (CUBI), Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany., Klinger B; Institute of Pathology, Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.; Institute of Biology, Humbolt-Universität zu Berlin, Berlin, Germany., Trinks A; Bioportal Single Cells, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117, Berlin, Germany., Sieber A; Institute of Pathology, Charité, Charité Universitätsmedizin Berlin, Berlin, Germany., Blüthgen N; Institute of Pathology, Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.; Institute of Biology, Humbolt-Universität zu Berlin, Berlin, Germany., Sawitzki B; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany. birgit.sawitzki@bih-charite.de.; Der Simulierte Mensch, a science framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany. birgit.sawitzki@bih-charite.de.
Source: EMBO reports [EMBO Rep] 2026 Apr; Vol. 27 (8), pp. 2029-2060. Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The AICL-KLRF1 axis supports CD4-CD8 T cell communication and cytokine competence in pre-exhausted CD8<superscript>+</superscript> T cells.
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  Data: <searchLink fieldCode="AU" term="%22Barone+M%22">Barone M</searchLink>; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Peidli+S%22">Peidli S</searchLink>; Institute of Pathology, Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.; Institute of Biology, Humbolt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Neuschulz+A%22">Neuschulz A</searchLink>; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Riesterer+K%22">Riesterer K</searchLink>; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Iwert+C%22">Iwert C</searchLink>; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Junquera+L%22">Junquera L</searchLink>; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sai+S%22">Sai S</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Bolaji+O%22">Bolaji O</searchLink>; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Bakoueva+D%22">Bakoueva D</searchLink>; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Appelt+C%22">Appelt C</searchLink>; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Obermayer+B%22">Obermayer B</searchLink>; Core Unit Bioinformatics (CUBI), Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Klinger+B%22">Klinger B</searchLink>; Institute of Pathology, Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.; Institute of Biology, Humbolt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Trinks+A%22">Trinks A</searchLink>; Bioportal Single Cells, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sieber+A%22">Sieber A</searchLink>; Institute of Pathology, Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Blüthgen+N%22">Blüthgen N</searchLink>; Institute of Pathology, Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.; Institute of Biology, Humbolt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sawitzki+B%22">Sawitzki B</searchLink>; Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany. birgit.sawitzki@bih-charite.de.; Der Simulierte Mensch, a science framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany. birgit.sawitzki@bih-charite.de.
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