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Targeting cardiomyocyte-derived extracellular vesicle miR-574-5p protects against cognitive impairment induced by ischemia-reperfusion.

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Title: Targeting cardiomyocyte-derived extracellular vesicle miR-574-5p protects against cognitive impairment induced by ischemia-reperfusion.
Authors: Chen E; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China., Zhu X; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China., Chang H; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China., Li Q; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China., Zhao Z; Department of Emergency Medicine, Institute of Disaster Medicine and Institute of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China., Zhang C; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China., Cao Y; Department of Emergency Medicine, Institute of Disaster Medicine and Institute of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China., Wang Y; Department of Biomedical Engineering, UAB, Birmingham, AL, USA., Ma X; Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA., Zhu T; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China., Zhang S; Department of Emergency Medicine, Institute of Disaster Medicine and Institute of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China. zhangs@wchscu.edu.cn., Gan L; Department of Emergency Medicine, Institute of Disaster Medicine and Institute of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China. ganlu@wchscu.cn., Liu J; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. liu_jin@scu.edu.cn.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China. liu_jin@scu.edu.cn., Chen C; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. chenchan@scu.edu.cn.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China. chenchan@scu.edu.cn.
Source: BMC medicine [BMC Med] 2026 Mar 19; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting cardiomyocyte-derived extracellular vesicle miR-574-5p protects against cognitive impairment induced by ischemia-reperfusion.
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  Data: <searchLink fieldCode="AU" term="%22Chen+E%22">Chen E</searchLink>; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Zhu+X%22">Zhu X</searchLink>; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Chang+H%22">Chang H</searchLink>; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Z%22">Zhao Z</searchLink>; Department of Emergency Medicine, Institute of Disaster Medicine and Institute of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; Department of Emergency Medicine, Institute of Disaster Medicine and Institute of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Biomedical Engineering, UAB, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Ma+X%22">Ma X</searchLink>; Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+T%22">Zhu T</searchLink>; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Emergency Medicine, Institute of Disaster Medicine and Institute of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China. zhangs@wchscu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Gan+L%22">Gan L</searchLink>; Department of Emergency Medicine, Institute of Disaster Medicine and Institute of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China. ganlu@wchscu.cn.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. liu_jin@scu.edu.cn.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China. liu_jin@scu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. chenchan@scu.edu.cn.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China. chenchan@scu.edu.cn.
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