VIBRANT: A phase 1 randomized trial of multi-strain vaginal L. crispatus live biotherapeutic products in people with bacterial vaginosis.

Saved in:
Bibliographic Details
Title: VIBRANT: A phase 1 randomized trial of multi-strain vaginal L. crispatus live biotherapeutic products in people with bacterial vaginosis.
Authors: Potloane D; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa., Symul L; Institute for Statistics, Biostatistics, and Actuarial Sciences (ISBA), Louvain Institute of Data Analysis and Modeling (LIDAM), Université Catholique de Louvain, Louvain-la-Neuve, Belgium., Ngcapu S; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Lewis L; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa., France M; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Vermeren L; Center for Support in Methodology and Statistical Calculation (SMCS), Louvain Institute of Data Analysis and Modeling (LIDAM), Université catholique de Louvain, Louvain-la-Neuve, Belgium., Elsherbini J; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA., Chetty C; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa., Mafunda NA; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA., Polliah AM; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa., Mtshali A; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Kama A; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa., Magini N; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Mitchev N; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa., Mzobe G; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Khan A; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA., Demidkina BC; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA., Goldenberg M; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA., Xu J; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA., Rutt L; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Shirtliff B; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Cook S; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Murthy M; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA., Hussain F; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA., Passmore JS; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa; National Health Laboratory Service, Cape Town, South Africa; DSI-NRF Centre of Excellence in HIV Prevention, Centre for the AIDS Program of Research in South Africa (CAPRISA), University of Cape Town, Cape Town, South Africa., Jaspan HB; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa; Seattle Children's Research Institute, Seattle, WA, USA; Departments of Pediatrics and Global Health, University of Washington, Seattle, WA, USA; Department of Pathology, University of Cape Town, South Africa., Kullin B; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa., Happel AU; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa., Liebenberg L; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa; Centre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Cape Town, South Africa., Relman DA; Department of Microbiology and Immunology, Stanford University, Palo Alto, CA, USA., Holmes S; Department of Statistics, Stanford University, Palo Alto, CA, USA., Kwon DS; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Division of Infectious Disease, Massachusetts General Hospital, Boston, MA, USA., Ravel J; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Mitchell CM; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Boston, MA, USA. Electronic address: caroline.mitchell@mgh.harvard.edu.
Source: Cell host & microbe [Cell Host Microbe] 2026 Apr 08; Vol. 34 (4), pp. 751-760.e5. Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1934-6069
DOI:10.1016/j.chom.2026.02.016