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VIBRANT: A phase 1 randomized trial of multi-strain vaginal L. crispatus live biotherapeutic products in people with bacterial vaginosis.

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Title: VIBRANT: A phase 1 randomized trial of multi-strain vaginal L. crispatus live biotherapeutic products in people with bacterial vaginosis.
Authors: Potloane D; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa., Symul L; Institute for Statistics, Biostatistics, and Actuarial Sciences (ISBA), Louvain Institute of Data Analysis and Modeling (LIDAM), Université Catholique de Louvain, Louvain-la-Neuve, Belgium., Ngcapu S; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Lewis L; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa., France M; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Vermeren L; Center for Support in Methodology and Statistical Calculation (SMCS), Louvain Institute of Data Analysis and Modeling (LIDAM), Université catholique de Louvain, Louvain-la-Neuve, Belgium., Elsherbini J; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA., Chetty C; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa., Mafunda NA; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA., Polliah AM; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa., Mtshali A; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Kama A; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa., Magini N; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Mitchev N; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa., Mzobe G; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Khan A; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA., Demidkina BC; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA., Goldenberg M; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA., Xu J; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA., Rutt L; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Shirtliff B; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Cook S; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Murthy M; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA., Hussain F; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA., Passmore JS; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa; National Health Laboratory Service, Cape Town, South Africa; DSI-NRF Centre of Excellence in HIV Prevention, Centre for the AIDS Program of Research in South Africa (CAPRISA), University of Cape Town, Cape Town, South Africa., Jaspan HB; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa; Seattle Children's Research Institute, Seattle, WA, USA; Departments of Pediatrics and Global Health, University of Washington, Seattle, WA, USA; Department of Pathology, University of Cape Town, South Africa., Kullin B; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa., Happel AU; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa., Liebenberg L; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa; Centre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Cape Town, South Africa., Relman DA; Department of Microbiology and Immunology, Stanford University, Palo Alto, CA, USA., Holmes S; Department of Statistics, Stanford University, Palo Alto, CA, USA., Kwon DS; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Division of Infectious Disease, Massachusetts General Hospital, Boston, MA, USA., Ravel J; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Mitchell CM; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Boston, MA, USA. Electronic address: caroline.mitchell@mgh.harvard.edu.
Source: Cell host & microbe [Cell Host Microbe] 2026 Apr 08; Vol. 34 (4), pp. 751-760.e5. Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: VIBRANT: A phase 1 randomized trial of multi-strain vaginal L. crispatus live biotherapeutic products in people with bacterial vaginosis.
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  Data: <searchLink fieldCode="AU" term="%22Potloane+D%22">Potloane D</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Symul+L%22">Symul L</searchLink>; Institute for Statistics, Biostatistics, and Actuarial Sciences (ISBA), Louvain Institute of Data Analysis and Modeling (LIDAM), Université Catholique de Louvain, Louvain-la-Neuve, Belgium.<br /><searchLink fieldCode="AU" term="%22Ngcapu+S%22">Ngcapu S</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Lewis+L%22">Lewis L</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22France+M%22">France M</searchLink>; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Vermeren+L%22">Vermeren L</searchLink>; Center for Support in Methodology and Statistical Calculation (SMCS), Louvain Institute of Data Analysis and Modeling (LIDAM), Université catholique de Louvain, Louvain-la-Neuve, Belgium.<br /><searchLink fieldCode="AU" term="%22Elsherbini+J%22">Elsherbini J</searchLink>; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chetty+C%22">Chetty C</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Mafunda+NA%22">Mafunda NA</searchLink>; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Polliah+AM%22">Polliah AM</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Mtshali+A%22">Mtshali A</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Kama+A%22">Kama A</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Magini+N%22">Magini N</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Mitchev+N%22">Mitchev N</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Mzobe+G%22">Mzobe G</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Khan+A%22">Khan A</searchLink>; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Demidkina+BC%22">Demidkina BC</searchLink>; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Goldenberg+M%22">Goldenberg M</searchLink>; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rutt+L%22">Rutt L</searchLink>; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Shirtliff+B%22">Shirtliff B</searchLink>; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Cook+S%22">Cook S</searchLink>; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Murthy+M%22">Murthy M</searchLink>; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hussain+F%22">Hussain F</searchLink>; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Passmore+JS%22">Passmore JS</searchLink>; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa; National Health Laboratory Service, Cape Town, South Africa; DSI-NRF Centre of Excellence in HIV Prevention, Centre for the AIDS Program of Research in South Africa (CAPRISA), University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Jaspan+HB%22">Jaspan HB</searchLink>; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa; Seattle Children's Research Institute, Seattle, WA, USA; Departments of Pediatrics and Global Health, University of Washington, Seattle, WA, USA; Department of Pathology, University of Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Kullin+B%22">Kullin B</searchLink>; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Happel+AU%22">Happel AU</searchLink>; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Liebenberg+L%22">Liebenberg L</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa; Centre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Relman+DA%22">Relman DA</searchLink>; Department of Microbiology and Immunology, Stanford University, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Holmes+S%22">Holmes S</searchLink>; Department of Statistics, Stanford University, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kwon+DS%22">Kwon DS</searchLink>; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Division of Infectious Disease, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ravel+J%22">Ravel J</searchLink>; Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mitchell+CM%22">Mitchell CM</searchLink>; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Boston, MA, USA. Electronic address: caroline.mitchell@mgh.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101302316%22">Cell host & microbe</searchLink> [Cell Host Microbe] 2026 Apr 08; Vol. 34 (4), pp. 751-760.e5. <i>Date of Electronic Publication: </i>2026 Mar 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101302316 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1934-6069 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219313128%22">19313128 </searchLink><i>NLM ISO Abbreviation: </i>Cell Host Microbe <i>Subsets: </i>MEDLINE
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