Parkinson's disease-associated PLA2G6 protects IP3R1 protein to control ER-mitochondria tethering and Ca2+ transfer.

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Title: Parkinson's disease-associated PLA2G6 protects IP3R1 protein to control ER-mitochondria tethering and Ca2+ transfer.
Authors: Lin ZH; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Xue NJ; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Liu Y; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Zhang F; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Si XL; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Zheng R; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Gu LY; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Li YL; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Fan Y; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Tian J; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Oertel WH; Department of Neurology, Philipps University Marburg, Marburg, Germany., Seo H; Department of Molecular & Life Sciences, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, South Korea., Pu JL; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. jialipu@zju.edu.cn., Zhang BR; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. brzhang@zju.edu.cn.
Source: Nature communications [Nat Commun] 2026 Mar 19; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-70752-1