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Parkinson's disease-associated PLA2G6 protects IP3R1 protein to control ER-mitochondria tethering and Ca2+ transfer.

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Title: Parkinson's disease-associated PLA2G6 protects IP3R1 protein to control ER-mitochondria tethering and Ca2+ transfer.
Authors: Lin ZH; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Xue NJ; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Liu Y; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Zhang F; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Si XL; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Zheng R; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Gu LY; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Li YL; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Fan Y; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Tian J; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Oertel WH; Department of Neurology, Philipps University Marburg, Marburg, Germany., Seo H; Department of Molecular & Life Sciences, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, South Korea., Pu JL; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. jialipu@zju.edu.cn., Zhang BR; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. brzhang@zju.edu.cn.
Source: Nature communications [Nat Commun] 2026 Mar 19; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Parkinson's disease-associated PLA2G6 protects IP3R1 protein to control ER-mitochondria tethering and Ca<superscript>2+</superscript> transfer.
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  Data: <searchLink fieldCode="AU" term="%22Lin+ZH%22">Lin ZH</searchLink>; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xue+NJ%22">Xue NJ</searchLink>; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+F%22">Zhang F</searchLink>; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Si+XL%22">Si XL</searchLink>; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zheng+R%22">Zheng R</searchLink>; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Gu+LY%22">Gu LY</searchLink>; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+YL%22">Li YL</searchLink>; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Fan+Y%22">Fan Y</searchLink>; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Tian+J%22">Tian J</searchLink>; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Oertel+WH%22">Oertel WH</searchLink>; Department of Neurology, Philipps University Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Seo+H%22">Seo H</searchLink>; Department of Molecular & Life Sciences, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, South Korea.<br /><searchLink fieldCode="AU" term="%22Pu+JL%22">Pu JL</searchLink>; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. jialipu@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+BR%22">Zhang BR</searchLink>; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. brzhang@zju.edu.cn.
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