Divergent macrophage responses to Influenza A virus and Streptococcus pneumoniae: co-infection drives bacterial dominance whereas superinfection favors viral priming.
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| Title: | Divergent macrophage responses to Influenza A virus and Streptococcus pneumoniae: co-infection drives bacterial dominance whereas superinfection favors viral priming. |
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| Authors: | Arranz-Herrero J; Transplant Immunology Unit, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain.; Microbiology Section, Dpto. Ciencias (CC), Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, Madrid, Spain.; Instituto de Medicina Molecular Aplicada-Nemesio Díez (IMMA-ND), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Baranda J; Transplant Immunology Unit, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain.; Microbiology Section, Dpto. Ciencias (CC), Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, Madrid, Spain.; Instituto de Medicina Molecular Aplicada-Nemesio Díez (IMMA-ND), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Rius-Rocabert S; Microbiology Section, Dpto. Ciencias (CC), Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, Madrid, Spain.; Instituto de Medicina Molecular Aplicada-Nemesio Díez (IMMA-ND), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Moreno-Vadillo M; Microbiology Section, Dpto. Ciencias (CC), Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, Madrid, Spain.; Instituto de Medicina Molecular Aplicada-Nemesio Díez (IMMA-ND), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Gonzalez-Ruiz I; Microbiology Section, Dpto. Ciencias (CC), Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, Madrid, Spain.; Instituto de Medicina Molecular Aplicada-Nemesio Díez (IMMA-ND), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Miranda-Bedate A; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands., Pinelli E; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands., Inchausti-Moya I; Microbiology Section, Dpto. Ciencias (CC), Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, Madrid, Spain.; Instituto de Medicina Molecular Aplicada-Nemesio Díez (IMMA-ND), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Izpura-Luis S; Microbiology Section, Dpto. Ciencias (CC), Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, Madrid, Spain.; Instituto de Medicina Molecular Aplicada-Nemesio Díez (IMMA-ND), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Tur-Planells V; Microbiology Section, Dpto. Ciencias (CC), Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, Madrid, Spain.; Instituto de Medicina Molecular Aplicada-Nemesio Díez (IMMA-ND), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Reche P; Microbiology Section, Dpto. Ciencias (CC), Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, Madrid, Spain., Fernandez P; Instituto de Medicina Molecular Aplicada-Nemesio Díez (IMMA-ND), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Revilla Y; Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain., Del Real G; Department of Biotechnology, National Institute of Agricultural and Food Research and Technology (INIA-CSIC), Madrid, Spain., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; The Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Gutiérrez-Martín CB; Department of Animal Health, Faculty of Veterinary, Universidad de León, León, Spain., Ochando J; Transplant Immunology Unit, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Nistal-Villan E; Microbiology Section, Dpto. Ciencias (CC), Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, Madrid, Spain.; Instituto de Medicina Molecular Aplicada-Nemesio Díez (IMMA-ND), Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain. |
| Source: | Frontiers in immunology [Front Immunol] 2026 Mar 04; Vol. 17, pp. 1729086. Date of Electronic Publication: 2026 Mar 04 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2026.1729086 |
