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EZH2 inhibition in resistant glioblastoma stem cells counteracts oxidative stress protection and triggers ferroptosis.

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Title: EZH2 inhibition in resistant glioblastoma stem cells counteracts oxidative stress protection and triggers ferroptosis.
Authors: Doualle C; Univ Angers, CHU Angers, Inserm, CNRS, MINT, SFR ICAT, Angers F-49000, France. Electronic address: cecile.doualle@orange.fr., Guérin M; Univ Angers, CHU Angers, Inserm, CNRS, MINT, SFR ICAT, Angers F-49000, France. Electronic address: melina.guerin@univ-angers.fr., Codron P; Laboratoire de Neurobiologie et Neuropathologie, Centre Hospitalier Universitaire d'Angers, Angers, France; Univ Angers, CHU Angers, INSERM U1083, CNRS 6015, MITOVASC, MITOLAB, SFR ICAT, Angers 49933, France. Electronic address: philippe.codron@chu-angers.fr., Spinazzi M; Laboratoire de Neurobiologie et Neuropathologie, Centre Hospitalier Universitaire d'Angers, Angers, France; Univ Angers, CHU Angers, INSERM U1083, CNRS 6015, MITOVASC, MITOLAB, SFR ICAT, Angers 49933, France. Electronic address: marco.spinazzi@chu-angers.fr., Tessier A; Pôle de biologie - pathologie, Centre Hospitalier Universitaire d'Angers, Angers, France. Electronic address: Anne.Tessier@chu-angers.fr., Lelièvre B; Laboratoire de pharmacologie/toxicologie, Centre Hospitalier Universitaire d'Angers, Angers, France. Electronic address: BeLelievre@chu-angers.fr., Delamotte M; Pharmacie à Usage Intérieur, Centre Hospitalier Universitaire d'Angers, Angers, France. Electronic address: margaux.delamotte@chu-angers.fr., Saulnier P; Univ Angers, CHU Angers, Inserm, CNRS, MINT, SFR ICAT, Angers F-49000, France; Laboratoire de Neurobiologie et Neuropathologie, Centre Hospitalier Universitaire d'Angers, Angers, France. Electronic address: patrick.saulnier@univ-angers.fr., Letournel F; Univ Angers, CHU Angers, Inserm, CNRS, MINT, SFR ICAT, Angers F-49000, France; Laboratoire de Neurobiologie et Neuropathologie, Centre Hospitalier Universitaire d'Angers, Angers, France. Electronic address: franck.letournel@univ-angers.fr., Gouju J; Univ Angers, CHU Angers, Inserm, CNRS, MINT, SFR ICAT, Angers F-49000, France; Laboratoire de Neurobiologie et Neuropathologie, Centre Hospitalier Universitaire d'Angers, Angers, France. Electronic address: Julien.Gouju@chu-angers.fr.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2026 May; Vol. 198, pp. 119254. Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1950-6007
DOI:10.1016/j.biopha.2026.119254