A dual catalytic architecture promotes C-2 stereoinversion of CDP-glucose by the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus.

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Title: A dual catalytic architecture promotes C-2 stereoinversion of CDP-glucose by the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus.
Authors: Rapp C; Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Graz, Austria., van Overtveldt S; Centre for Synthetic Biology, Department of Biotechnology, Ghent University, Ghent, Belgium., Sánchez-Murcia PA; Laboratory of Computer-Aided Molecular Design, Division of Medicinal Chemistry, Otto- Loewi Research Center, Medical University of Graz, BioTechMed-Graz, Graz, Austria., Pfeiffer M; Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Graz, Austria., Beerens K; Centre for Synthetic Biology, Department of Biotechnology, Ghent University, Ghent, Belgium., Merkaš M; Institute of Molecular Biotechnology, Graz University of Technology, NAWI Graz, Graz, Austria., Pavkov-Keller T; Institute of Molecular Biosciences, University of Graz, Graz, Austria., Desmet T; Centre for Synthetic Biology, Department of Biotechnology, Ghent University, Ghent, Belgium; Austrian Centre of Industrial Biotechnology (acib), Graz, Austria., Nidetzky B; Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Graz, Austria; Austrian Centre of Industrial Biotechnology (acib), Graz, Austria. Electronic address: bernd.nidetzky@tugraz.at.
Source: The Journal of biological chemistry [J Biol Chem] 2026 May; Vol. 302 (5), pp. 111384. Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1083-351X
DOI:10.1016/j.jbc.2026.111384