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A dual catalytic architecture promotes C-2 stereoinversion of CDP-glucose by the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus.

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Title: A dual catalytic architecture promotes C-2 stereoinversion of CDP-glucose by the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus.
Authors: Rapp C; Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Graz, Austria., van Overtveldt S; Centre for Synthetic Biology, Department of Biotechnology, Ghent University, Ghent, Belgium., Sánchez-Murcia PA; Laboratory of Computer-Aided Molecular Design, Division of Medicinal Chemistry, Otto- Loewi Research Center, Medical University of Graz, BioTechMed-Graz, Graz, Austria., Pfeiffer M; Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Graz, Austria., Beerens K; Centre for Synthetic Biology, Department of Biotechnology, Ghent University, Ghent, Belgium., Merkaš M; Institute of Molecular Biotechnology, Graz University of Technology, NAWI Graz, Graz, Austria., Pavkov-Keller T; Institute of Molecular Biosciences, University of Graz, Graz, Austria., Desmet T; Centre for Synthetic Biology, Department of Biotechnology, Ghent University, Ghent, Belgium; Austrian Centre of Industrial Biotechnology (acib), Graz, Austria., Nidetzky B; Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Graz, Austria; Austrian Centre of Industrial Biotechnology (acib), Graz, Austria. Electronic address: bernd.nidetzky@tugraz.at.
Source: The Journal of biological chemistry [J Biol Chem] 2026 May; Vol. 302 (5), pp. 111384. Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A dual catalytic architecture promotes C-2 stereoinversion of CDP-glucose by the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus.
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  Data: <searchLink fieldCode="AU" term="%22Rapp+C%22">Rapp C</searchLink>; Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22van+Overtveldt+S%22">van Overtveldt S</searchLink>; Centre for Synthetic Biology, Department of Biotechnology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Sánchez-Murcia+PA%22">Sánchez-Murcia PA</searchLink>; Laboratory of Computer-Aided Molecular Design, Division of Medicinal Chemistry, Otto- Loewi Research Center, Medical University of Graz, BioTechMed-Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Pfeiffer+M%22">Pfeiffer M</searchLink>; Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Beerens+K%22">Beerens K</searchLink>; Centre for Synthetic Biology, Department of Biotechnology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Merkaš+M%22">Merkaš M</searchLink>; Institute of Molecular Biotechnology, Graz University of Technology, NAWI Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Pavkov-Keller+T%22">Pavkov-Keller T</searchLink>; Institute of Molecular Biosciences, University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Desmet+T%22">Desmet T</searchLink>; Centre for Synthetic Biology, Department of Biotechnology, Ghent University, Ghent, Belgium; Austrian Centre of Industrial Biotechnology (acib), Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Nidetzky+B%22">Nidetzky B</searchLink>; Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Graz, Austria; Austrian Centre of Industrial Biotechnology (acib), Graz, Austria. Electronic address: bernd.nidetzky@tugraz.at.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2026 May; Vol. 302 (5), pp. 111384. <i>Date of Electronic Publication: </i>2026 Mar 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jbc.2026.111384
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              Text: 2026 May
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