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ALS mutations disrupt self-association between the ubiquilin STI1 hydrophobic groove and internal placeholder sequences.

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Title: ALS mutations disrupt self-association between the ubiquilin STI1 hydrophobic groove and internal placeholder sequences.
Authors: Onwunma J; Department of Chemistry & Biochemistry, University of Toledo, Toledo, OH, USA., Binsabaan S; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA., Allen SP; Department of Chemistry & Biochemistry, University of Toledo, Toledo, OH, USA.; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA., Thanthirige SR; Department of Chemistry & Biochemistry, University of Toledo, Toledo, OH, USA.; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA., Gaur D; Department of Chemistry & Biochemistry, University of Toledo, Toledo, OH, USA.; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA., Sankaran B; Lawrence Berkeley National Lab, Berkeley Center for Structural Biology, Molecular Biophysics and Integrated Bioimaging, Berkeley, CA, USA., Wohlever ML; Department of Chemistry & Biochemistry, University of Toledo, Toledo, OH, USA. wohlever@pitt.edu.; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA. wohlever@pitt.edu.
Source: The EMBO journal [EMBO J] 2026 Apr; Vol. 45 (8), pp. 2694-2711. Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Onwunma+J%22">Onwunma J</searchLink>; Department of Chemistry & Biochemistry, University of Toledo, Toledo, OH, USA.<br /><searchLink fieldCode="AU" term="%22Binsabaan+S%22">Binsabaan S</searchLink>; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Allen+SP%22">Allen SP</searchLink>; Department of Chemistry & Biochemistry, University of Toledo, Toledo, OH, USA.; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Thanthirige+SR%22">Thanthirige SR</searchLink>; Department of Chemistry & Biochemistry, University of Toledo, Toledo, OH, USA.; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gaur+D%22">Gaur D</searchLink>; Department of Chemistry & Biochemistry, University of Toledo, Toledo, OH, USA.; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sankaran+B%22">Sankaran B</searchLink>; Lawrence Berkeley National Lab, Berkeley Center for Structural Biology, Molecular Biophysics and Integrated Bioimaging, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wohlever+ML%22">Wohlever ML</searchLink>; Department of Chemistry & Biochemistry, University of Toledo, Toledo, OH, USA. wohlever@pitt.edu.; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA. wohlever@pitt.edu.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 Apr; Vol. 45 (8), pp. 2694-2711. <i>Date of Electronic Publication: </i>2026 Mar 20.
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        Value: 10.1038/s44318-026-00745-9
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