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Oral sodium butyrate supplementation acts on intestinal dysbiosis and resolves spinal cord neuroinflammation and nociceptive neuron sensitization.

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Title: Oral sodium butyrate supplementation acts on intestinal dysbiosis and resolves spinal cord neuroinflammation and nociceptive neuron sensitization.
Authors: Fusco A; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy., Ricciardi F; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy., Perrone M; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy., Di Martino E; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy., Limongelli R; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy., Morace AM; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy., Finamore R; Department of Experimental Medicine, Section of Biotechnology, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy., Bonsale R; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy., Belardo C; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy., Trotta MC; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy., Iannotti FA; Institute of Biomolecular Chemistry (ICB), National Research Council of Italy (CNR), 80078, Pozzuoli, NA, Italy., Infantino R; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy.; Pharmacology and Therapeutics, School of Pharmacy and Medical Sciences, University of Galway, Galway, Ireland., Luongo L; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy., Schiraldi C; Department of Experimental Medicine, Section of Biotechnology, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy., Di Marzo V; Institute of Biomolecular Chemistry (ICB), National Research Council of Italy (CNR), 80078, Pozzuoli, NA, Italy.; Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health, Faculty of Medicine and Faculty of Agricultural and Food Sciences, Université Laval, Québec City, QC, Canada.; Heart and Lung Research Institute of Université Laval, Québec City, QC, Canada.; Institute for Nutrition and Functional Foods, Centre NUTRISS, Université Laval, Québec City, QC, Canada., Maione S; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy., Gatta A; Department of Experimental Medicine, Section of Biotechnology, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy., Guida F; Department of Experimental Medicine, Pharmacology Division, University of Campania 'L. Vanvitelli', 80138, Napoli, Italy. francesca.guida@unicampania.it.
Source: Journal of inflammation (London, England) [J Inflamm (Lond)] 2026 Mar 20; Vol. 23 (1). Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101232234 Publication Model: Electronic Cited Medium: Print ISSN: 1476-9255 (Print) Linking ISSN: 14769255 NLM ISO Abbreviation: J Inflamm (Lond) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-9255
DOI:10.1186/s12950-026-00496-8