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Raloxifene injections normalize age-related mechanical sensitization in female and male mice and augment intervertebral disc structure in old female mice.

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Title: Raloxifene injections normalize age-related mechanical sensitization in female and male mice and augment intervertebral disc structure in old female mice.
Authors: Bhadouria N; Dept. of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Huang JJ; Dept. of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Augustin J; Dept. of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Wang B; Ctr. for Biotech. & Interdisciplinary Studies, Rensselaer Polytechnic Institute, New York, NY, United States; Ctr. for Eng. & Precision Medicine, Rensselaer-Icahn School of Medicine at Mount Sinai, New York, NY, United States., Almeida JI; Dept. of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Kroon T; Dept. of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Manolis J; Dept. of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Lemonick M; Dept. of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Seifert A; Biomedical Engineering and Imaging Institute, Dept. of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Vashishth D; Ctr. for Biotech. & Interdisciplinary Studies, Rensselaer Polytechnic Institute, New York, NY, United States; Ctr. for Eng. & Precision Medicine, Rensselaer-Icahn School of Medicine at Mount Sinai, New York, NY, United States., Iatridis JC; Dept. of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Ctr. for Eng. & Precision Medicine, Rensselaer-Icahn School of Medicine at Mount Sinai, New York, NY, United States., Holguin N; Dept. of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Ctr. for Eng. & Precision Medicine, Rensselaer-Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: Nilsson.Holguin@mssm.edu.
Source: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2026 Jul; Vol. 34 (7), pp. 1063-1074. Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: W.B. Saunders For The Osteoarthritis Research Society Country of Publication: England NLM ID: 9305697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-9653 (Electronic) Linking ISSN: 10634584 NLM ISO Abbreviation: Osteoarthritis Cartilage Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1522-9653
DOI:10.1016/j.joca.2026.03.118