Towards high-quality and timely interim analyses in adaptive trials: a scoping review of best practice and evidence gaps.

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Bibliographic Details
Title: Towards high-quality and timely interim analyses in adaptive trials: a scoping review of best practice and evidence gaps.
Authors: Thomson KH; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK. katie.thomson@newcastle.ac.uk.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK. katie.thomson@newcastle.ac.uk., Agbeleye O; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK., Oparah C; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK., Inskip A; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK., Breckons M; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK., Bardgett M; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK., Bevin-Nicholls A; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK., Hancock H; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK., Mossop H; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK., Phillipson J; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK., Teare D; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK., Walmsley Z; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK., Wilson N; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK., Craig D; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK., Wason JMS; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.
Source: Trials [Trials] 2026 Mar 21; Vol. 27 (1). Date of Electronic Publication: 2026 Mar 21.
Publication Type: Journal Article; Scoping Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1745-6215
DOI:10.1186/s13063-026-09643-1