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Towards high-quality and timely interim analyses in adaptive trials: a scoping review of best practice and evidence gaps.

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Title: Towards high-quality and timely interim analyses in adaptive trials: a scoping review of best practice and evidence gaps.
Authors: Thomson KH; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK. katie.thomson@newcastle.ac.uk.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK. katie.thomson@newcastle.ac.uk., Agbeleye O; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK., Oparah C; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK., Inskip A; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK., Breckons M; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK., Bardgett M; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK., Bevin-Nicholls A; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK., Hancock H; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK., Mossop H; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK., Phillipson J; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK., Teare D; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK., Walmsley Z; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK., Wilson N; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK., Craig D; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK., Wason JMS; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.
Source: Trials [Trials] 2026 Mar 21; Vol. 27 (1). Date of Electronic Publication: 2026 Mar 21.
Publication Type: Journal Article; Scoping Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Towards high-quality and timely interim analyses in adaptive trials: a scoping review of best practice and evidence gaps.
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  Data: <searchLink fieldCode="AU" term="%22Thomson+KH%22">Thomson KH</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK. katie.thomson@newcastle.ac.uk.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK. katie.thomson@newcastle.ac.uk.<br /><searchLink fieldCode="AU" term="%22Agbeleye+O%22">Agbeleye O</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK.<br /><searchLink fieldCode="AU" term="%22Oparah+C%22">Oparah C</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK.<br /><searchLink fieldCode="AU" term="%22Inskip+A%22">Inskip A</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK.<br /><searchLink fieldCode="AU" term="%22Breckons+M%22">Breckons M</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.<br /><searchLink fieldCode="AU" term="%22Bardgett+M%22">Bardgett M</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK.<br /><searchLink fieldCode="AU" term="%22Bevin-Nicholls+A%22">Bevin-Nicholls A</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.<br /><searchLink fieldCode="AU" term="%22Hancock+H%22">Hancock H</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK.<br /><searchLink fieldCode="AU" term="%22Mossop+H%22">Mossop H</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.<br /><searchLink fieldCode="AU" term="%22Phillipson+J%22">Phillipson J</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK.<br /><searchLink fieldCode="AU" term="%22Teare+D%22">Teare D</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK.<br /><searchLink fieldCode="AU" term="%22Walmsley+Z%22">Walmsley Z</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; Newcastle Clinical Trials Unit, Population Health Sciences Institute, Newcastle University, 1-4 Claremont Terrace, Newcastle Upon Tyne, NE2 4AE, UK.<br /><searchLink fieldCode="AU" term="%22Wilson+N%22">Wilson N</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.<br /><searchLink fieldCode="AU" term="%22Craig+D%22">Craig D</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, The Catalyst, Science Square, Newcastle Helix, Newcastle Upon Tyne, NE4 5TG, UK.<br /><searchLink fieldCode="AU" term="%22Wason+JMS%22">Wason JMS</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4BN, UK.
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        Value: 10.1186/s13063-026-09643-1
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