Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan.

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Title: Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan.
Authors: Pascual JR; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Rivera I; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Nguyen H; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Ngo PT; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Hoang A; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Andrews EJ; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Rouanet J; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Wright ST; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Sordo L; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Kofler J; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Geriatric Research Education and Clinical Center, Pittsburgh VA Healthcare System, Pittsburgh, PA, USA., Ikonomovic MD; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Geriatric Research Education and Clinical Center, Pittsburgh VA Healthcare System, Pittsburgh, PA, USA.; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Lai F; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Mapstone M; Department of Neurology, University of California, Irvine, Irvine, CA, USA., Christian BT; Departments of Medical Physics and Psychiatry, Waisman Center, University of Wisconsin-Madison, Madison, WI, USA., Handen BL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Lott IT; Department of Pediatrics, University of California, Irvine, CA, USA., Doran E; Department of Pediatrics, University of California, Irvine, CA, USA., Hom CL; Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA., Harp J; Department of Neurology, University of Kentucky, Lexington, KY, USA., Schmitt F; Department of Neurology, University of Kentucky, Lexington, KY, USA.; Sanders-Brown Center On Aging, University of Kentucky, Lexington, KY, USA., Tudorascu DL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Ances BM; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Phelan M; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Liu L; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Flores-Aguilar L; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA., Head E; Department of Pathology and Laboratory Medicine, 1111 Gillespie Neuroscience Research Facility, University of California, Irvine, CA, 92697, USA. heade@uci.edu.
Corporate Authors: Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators
Source: Acta neuropathologica [Acta Neuropathol] 2026 Mar 22; Vol. 151 (1). Date of Electronic Publication: 2026 Mar 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0533
DOI:10.1007/s00401-026-02994-8