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Discovery and computational characterization of a novel cryptic pocket in human farnesyl pyrophosphate synthase.

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Title: Discovery and computational characterization of a novel cryptic pocket in human farnesyl pyrophosphate synthase.
Authors: Pandya V; Department of Biochemistry, Memorial University of Newfoundland, 45 Arctic Avenue, St. John's, Newfoundland and Labrador A1C 5S7, Canada., Wilson KA; Department of Biochemistry, Memorial University of Newfoundland, 45 Arctic Avenue, St. John's, Newfoundland and Labrador A1C 5S7, Canada., Leung CY; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada., Tsantrizos YS; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada., Park J; Department of Biochemistry, Memorial University of Newfoundland, 45 Arctic Avenue, St. John's, Newfoundland and Labrador A1C 5S7, Canada. Electronic address: Jaeok.park@mun.ca.
Source: Journal of structural biology [J Struct Biol] 2026 Jun; Vol. 218 (2), pp. 108316. Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9011206 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8657 (Electronic) Linking ISSN: 10478477 NLM ISO Abbreviation: J Struct Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery and computational characterization of a novel cryptic pocket in human farnesyl pyrophosphate synthase.
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  Data: <searchLink fieldCode="AU" term="%22Pandya+V%22">Pandya V</searchLink>; Department of Biochemistry, Memorial University of Newfoundland, 45 Arctic Avenue, St. John's, Newfoundland and Labrador A1C 5S7, Canada.<br /><searchLink fieldCode="AU" term="%22Wilson+KA%22">Wilson KA</searchLink>; Department of Biochemistry, Memorial University of Newfoundland, 45 Arctic Avenue, St. John's, Newfoundland and Labrador A1C 5S7, Canada.<br /><searchLink fieldCode="AU" term="%22Leung+CY%22">Leung CY</searchLink>; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.<br /><searchLink fieldCode="AU" term="%22Tsantrizos+YS%22">Tsantrizos YS</searchLink>; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Department of Biochemistry, Memorial University of Newfoundland, 45 Arctic Avenue, St. John's, Newfoundland and Labrador A1C 5S7, Canada. Electronic address: Jaeok.park@mun.ca.
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  Data: <searchLink fieldCode="JN" term="%229011206%22">Journal of structural biology</searchLink> [J Struct Biol] 2026 Jun; Vol. 218 (2), pp. 108316. <i>Date of Electronic Publication: </i>2026 Mar 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9011206 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-8657 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210478477%22">10478477 </searchLink><i>NLM ISO Abbreviation: </i>J Struct Biol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jsb.2026.108316
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        Text: English
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            NameFull: Pandya V
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            NameFull: Wilson KA
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            NameFull: Leung CY
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            – D: 01
              M: 06
              Text: 2026 Jun
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