Preclinical efficacy and safety evaluation of human embryonic stem cell-derived functional hepatocytes for a clinical trial in acute liver failure.

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Title: Preclinical efficacy and safety evaluation of human embryonic stem cell-derived functional hepatocytes for a clinical trial in acute liver failure.
Authors: Sun Y; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China.; Hunan Guangxiu Hospital, Changsha, China., Yu J; National Engineering and Research Center of Human Stem Cells, Changsha, China., Shi Y; National Engineering and Research Center of Human Stem Cells, Changsha, China., Wang Y; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China., Duan X; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China., Xie M; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China., Ouyang Q; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China., Zhao Y; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China., Wang M; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China., Zhou B; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China., Xu C; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China.; Hunan Guangxiu Hospital, Changsha, China., Lu G; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China.; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China.; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China., Lin G; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China. linggf@hotmail.com.; National Engineering and Research Center of Human Stem Cells, Changsha, China. linggf@hotmail.com.; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China. linggf@hotmail.com.; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China. linggf@hotmail.com.
Source: Stem cell research & therapy [Stem Cell Res Ther] 2026 Mar 23; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1757-6512
DOI:10.1186/s13287-026-04985-8