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Preclinical efficacy and safety evaluation of human embryonic stem cell-derived functional hepatocytes for a clinical trial in acute liver failure.

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Title: Preclinical efficacy and safety evaluation of human embryonic stem cell-derived functional hepatocytes for a clinical trial in acute liver failure.
Authors: Sun Y; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China.; Hunan Guangxiu Hospital, Changsha, China., Yu J; National Engineering and Research Center of Human Stem Cells, Changsha, China., Shi Y; National Engineering and Research Center of Human Stem Cells, Changsha, China., Wang Y; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China., Duan X; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China., Xie M; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China., Ouyang Q; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China., Zhao Y; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China., Wang M; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China., Zhou B; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China., Xu C; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China.; Hunan Guangxiu Hospital, Changsha, China., Lu G; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China.; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China.; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China., Lin G; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China. linggf@hotmail.com.; National Engineering and Research Center of Human Stem Cells, Changsha, China. linggf@hotmail.com.; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China. linggf@hotmail.com.; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China. linggf@hotmail.com.
Source: Stem cell research & therapy [Stem Cell Res Ther] 2026 Mar 23; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Preclinical efficacy and safety evaluation of human embryonic stem cell-derived functional hepatocytes for a clinical trial in acute liver failure.
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  Data: <searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China.; Hunan Guangxiu Hospital, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; National Engineering and Research Center of Human Stem Cells, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; National Engineering and Research Center of Human Stem Cells, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Duan+X%22">Duan X</searchLink>; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Xie+M%22">Xie M</searchLink>; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Ouyang+Q%22">Ouyang Q</searchLink>; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Zhou+B%22">Zhou B</searchLink>; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China.; Hunan Guangxiu Hospital, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Lu+G%22">Lu G</searchLink>; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.; National Engineering and Research Center of Human Stem Cells, Changsha, China.; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China.; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China.; Hunan Guangxiu High-tech Life Science and Technology Co., Ltd, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Lin+G%22">Lin G</searchLink>; Institute of Reproductive and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China. linggf@hotmail.com.; National Engineering and Research Center of Human Stem Cells, Changsha, China. linggf@hotmail.com.; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China. linggf@hotmail.com.; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China. linggf@hotmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101527581%22">Stem cell research & therapy</searchLink> [Stem Cell Res Ther] 2026 Mar 23; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Mar 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101527581 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-6512 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217576512%22">17576512 </searchLink><i>NLM ISO Abbreviation: </i>Stem Cell Res Ther <i>Subsets: </i>MEDLINE
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              Text: 2026 Mar 23
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