Low-dose naltrexone as an adjunctive treatment for major depressive disorder: findings from a randomized, double-blind, placebo-controlled hybrid parallel-arm study.

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Title: Low-dose naltrexone as an adjunctive treatment for major depressive disorder: findings from a randomized, double-blind, placebo-controlled hybrid parallel-arm study.
Authors: Moloney BD; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Forsyth A; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Sumner RL; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Department of Biomedicine and Medical Diagnostics, Auckland University of Technology, Auckland, New Zealand., Glover SC; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Hoeh NR; Department of Psychological Medicine, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Sundram F; Department of Psychological Medicine, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Cavadino A; Department of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Muthukumaraswamy S; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Lin JC; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Mar 06; Vol. 17, pp. 1767654. Date of Electronic Publication: 2026 Mar 06 (Print Publication: 2026).
Publication Type: Clinical Trial; Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:1663-9812
DOI:10.3389/fphar.2026.1767654