Low-dose naltrexone as an adjunctive treatment for major depressive disorder: findings from a randomized, double-blind, placebo-controlled hybrid parallel-arm study.

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Title: Low-dose naltrexone as an adjunctive treatment for major depressive disorder: findings from a randomized, double-blind, placebo-controlled hybrid parallel-arm study.
Authors: Moloney BD; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Forsyth A; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Sumner RL; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Department of Biomedicine and Medical Diagnostics, Auckland University of Technology, Auckland, New Zealand., Glover SC; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Hoeh NR; Department of Psychological Medicine, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Sundram F; Department of Psychological Medicine, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Cavadino A; Department of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Muthukumaraswamy S; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Lin JC; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Mar 06; Vol. 17, pp. 1767654. Date of Electronic Publication: 2026 Mar 06 (Print Publication: 2026).
Publication Type: Clinical Trial; Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
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  Data: Low-dose naltrexone as an adjunctive treatment for major depressive disorder: findings from a randomized, double-blind, placebo-controlled hybrid parallel-arm study.
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  Data: <searchLink fieldCode="AU" term="%22Moloney+BD%22">Moloney BD</searchLink>; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Forsyth+A%22">Forsyth A</searchLink>; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Sumner+RL%22">Sumner RL</searchLink>; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Department of Biomedicine and Medical Diagnostics, Auckland University of Technology, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Glover+SC%22">Glover SC</searchLink>; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Hoeh+NR%22">Hoeh NR</searchLink>; Department of Psychological Medicine, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Sundram+F%22">Sundram F</searchLink>; Department of Psychological Medicine, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Cavadino+A%22">Cavadino A</searchLink>; Department of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Muthukumaraswamy+S%22">Muthukumaraswamy S</searchLink>; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Lin+JC%22">Lin JC</searchLink>; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media]%22">Frontiers Media] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101548923 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1663-9812 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216639812%22">16639812 </searchLink><i>NLM ISO Abbreviation: </i>Front Pharmacol <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Mar 06
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