Mucosal tenofovir 1% gel stimulates cell proliferation and type I/III interferon pathways.

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Title: Mucosal tenofovir 1% gel stimulates cell proliferation and type I/III interferon pathways.
Authors: Hughes SM; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA., Calienes FL; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA., Levy CN; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA., Pandey U; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA., Gornalusse GG; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA., Cranston RD; Department of Infectious Diseases and Dermatology, University of Barcelona, Barcelona, Spain., Lama JR; Asociación Civil Impacta Salud y Educación, Lima, Peru., Pickett J; Jim Pickett Consulting, Chicago, Illinois, USA., Brand RM; Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA., Hendrix CW; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Marzinke MA; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Dai JY; Division of Public Health Sciences, Fred Hutch Cancer Center, Seattle, Washington, USA., Balar B; Division of Gastroenterology, Department of Medicine, Bronxcare, New York, New York, USA., Justman JE; Department of Epidemiology, ICAP at Columbia University, Columbia University, New York, New York, USA.; Department of Medicine, ICAP at Columbia University, Columbia University, New York, New York, USA., Nair G; Desmond Tutu HIV Centre, Cape Town, South Africa.; Centre for Medical Ethics and Law, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa., Berard AR; Department of Obstetrics, Gynecology & Reproductive Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.; Department of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA., Birse K; University of Calgary, Calgary, Alberta, Canada., Noel-Romas L; Department of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Obstetrics & Gynecology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada., Mayer KH; The Fenway Institute of Fenway Health, Boston, Massachusetts, USA.; Fenway Health, Boston, Massachusetts, USA.; Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Stekler JD; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Department of Medicine, University of Washington, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA., Mackelprang R; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA., Burgener AD; Department of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Obstetrics & Gynecology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.; Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden., McGowan I; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA., Cameron CM; Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Cameron MJ; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Woodrow KA; Department of Bioengineering, University of Washington, Seattle, Washington, USA., Hladik F; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.; Vaccine and Infectious Disease Division, Fred Hutch Cancer Center, Seattle, Washington, USA.; Department of Medicine, University of Washington, Seattle, Washington, USA.
Source: Microbiology spectrum [Microbiol Spectr] 2026 Mar 23, pp. e0168025. Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2165-0497
DOI:10.1128/spectrum.01680-25