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Mucosal tenofovir 1% gel stimulates cell proliferation and type I/III interferon pathways.

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Title: Mucosal tenofovir 1% gel stimulates cell proliferation and type I/III interferon pathways.
Authors: Hughes SM; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA., Calienes FL; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA., Levy CN; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA., Pandey U; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA., Gornalusse GG; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA., Cranston RD; Department of Infectious Diseases and Dermatology, University of Barcelona, Barcelona, Spain., Lama JR; Asociación Civil Impacta Salud y Educación, Lima, Peru., Pickett J; Jim Pickett Consulting, Chicago, Illinois, USA., Brand RM; Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA., Hendrix CW; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Marzinke MA; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Dai JY; Division of Public Health Sciences, Fred Hutch Cancer Center, Seattle, Washington, USA., Balar B; Division of Gastroenterology, Department of Medicine, Bronxcare, New York, New York, USA., Justman JE; Department of Epidemiology, ICAP at Columbia University, Columbia University, New York, New York, USA.; Department of Medicine, ICAP at Columbia University, Columbia University, New York, New York, USA., Nair G; Desmond Tutu HIV Centre, Cape Town, South Africa.; Centre for Medical Ethics and Law, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa., Berard AR; Department of Obstetrics, Gynecology & Reproductive Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.; Department of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA., Birse K; University of Calgary, Calgary, Alberta, Canada., Noel-Romas L; Department of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Obstetrics & Gynecology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada., Mayer KH; The Fenway Institute of Fenway Health, Boston, Massachusetts, USA.; Fenway Health, Boston, Massachusetts, USA.; Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Stekler JD; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Department of Medicine, University of Washington, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA., Mackelprang R; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA., Burgener AD; Department of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Obstetrics & Gynecology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.; Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden., McGowan I; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA., Cameron CM; Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Cameron MJ; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Woodrow KA; Department of Bioengineering, University of Washington, Seattle, Washington, USA., Hladik F; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.; Vaccine and Infectious Disease Division, Fred Hutch Cancer Center, Seattle, Washington, USA.; Department of Medicine, University of Washington, Seattle, Washington, USA.
Source: Microbiology spectrum [Microbiol Spectr] 2026 Mar 23, pp. e0168025. Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE
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  Data: Mucosal tenofovir 1% gel stimulates cell proliferation and type I/III interferon pathways.
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  Data: <searchLink fieldCode="AU" term="%22Hughes+SM%22">Hughes SM</searchLink>; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Calienes+FL%22">Calienes FL</searchLink>; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Levy+CN%22">Levy CN</searchLink>; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Pandey+U%22">Pandey U</searchLink>; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Gornalusse+GG%22">Gornalusse GG</searchLink>; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Cranston+RD%22">Cranston RD</searchLink>; Department of Infectious Diseases and Dermatology, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Lama+JR%22">Lama JR</searchLink>; Asociación Civil Impacta Salud y Educación, Lima, Peru.<br /><searchLink fieldCode="AU" term="%22Pickett+J%22">Pickett J</searchLink>; Jim Pickett Consulting, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Brand+RM%22">Brand RM</searchLink>; Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Hendrix+CW%22">Hendrix CW</searchLink>; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Marzinke+MA%22">Marzinke MA</searchLink>; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Dai+JY%22">Dai JY</searchLink>; Division of Public Health Sciences, Fred Hutch Cancer Center, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Balar+B%22">Balar B</searchLink>; Division of Gastroenterology, Department of Medicine, Bronxcare, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Justman+JE%22">Justman JE</searchLink>; Department of Epidemiology, ICAP at Columbia University, Columbia University, New York, New York, USA.; Department of Medicine, ICAP at Columbia University, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Nair+G%22">Nair G</searchLink>; Desmond Tutu HIV Centre, Cape Town, South Africa.; Centre for Medical Ethics and Law, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.<br /><searchLink fieldCode="AU" term="%22Berard+AR%22">Berard AR</searchLink>; Department of Obstetrics, Gynecology & Reproductive Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.; Department of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Birse+K%22">Birse K</searchLink>; University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Noel-Romas+L%22">Noel-Romas L</searchLink>; Department of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Obstetrics & Gynecology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Mayer+KH%22">Mayer KH</searchLink>; The Fenway Institute of Fenway Health, Boston, Massachusetts, USA.; Fenway Health, Boston, Massachusetts, USA.; Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Stekler+JD%22">Stekler JD</searchLink>; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Department of Medicine, University of Washington, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Mackelprang+R%22">Mackelprang R</searchLink>; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Burgener+AD%22">Burgener AD</searchLink>; Department of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Obstetrics & Gynecology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.; Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22McGowan+I%22">McGowan I</searchLink>; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Cameron+CM%22">Cameron CM</searchLink>; Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Cameron+MJ%22">Cameron MJ</searchLink>; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Woodrow+KA%22">Woodrow KA</searchLink>; Department of Bioengineering, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Hladik+F%22">Hladik F</searchLink>; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.; Vaccine and Infectious Disease Division, Fred Hutch Cancer Center, Seattle, Washington, USA.; Department of Medicine, University of Washington, Seattle, Washington, USA.
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