Dysfunction of α2δ4 leads to photoreceptor degeneration through disrupted synaptic mitochondria and calcium crosstalk.

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Title: Dysfunction of α2δ4 leads to photoreceptor degeneration through disrupted synaptic mitochondria and calcium crosstalk.
Authors: Amieghemen CI; Department of Optometry and Vision Science, The University of Alabama at Birmingham, Birmingham, AL, USA., Ung TT; Department of Optometry and Vision Science, The University of Alabama at Birmingham, Birmingham, AL, USA., Huskin GN; Department of Optometry and Vision Science, The University of Alabama at Birmingham, Birmingham, AL, USA., Mobley JA; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, The University of Alabama at Birmingham, Birmingham, AL, USA., Chimento MF; Institutional Research Core Program, High Resolution Imaging Facility, The University of Alabama at Birmingham, Birmingham, AL, USA., Nguyen M; Department of Optometry and Vision Science, The University of Alabama at Birmingham, Birmingham, AL, USA., Fortenberry J; Department of Optometry and Vision Science, The University of Alabama at Birmingham, Birmingham, AL, USA., Kraft TW; Department of Optometry and Vision Science, The University of Alabama at Birmingham, Birmingham, AL, USA., Pittler SJ; Department of Optometry and Vision Science, The University of Alabama at Birmingham, Birmingham, AL, USA., Wang Y; Department of Optometry and Vision Science, The University of Alabama at Birmingham, Birmingham, AL, USA. wangyc@uab.edu.
Source: Cell death & disease [Cell Death Dis] 2026 Mar 23; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-026-08587-3