Optimizing CRISPR precision in mouse embryos via microhomology-mediated end joining-dominant targeting.
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| Title: | Optimizing CRISPR precision in mouse embryos via microhomology-mediated end joining-dominant targeting. |
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| Authors: | Lkhagvadorj K; Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science, Otsu, Shiga, Japan., Okamura E; Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science, Otsu, Shiga, Japan. eiokamu@belle.shiga-med.ac.jp., Taki T; Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba, Tsukuba, Ibaraki, Japan., Suzuki H; Laboratory Animal Resource Center in Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan., Kuno A; Laboratory Animal Resource Center in Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.; Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.; Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, Japan., Itoh Y; Division of Pathogenesis and Disease Regulation, Department of Pathology and Central Research Laboratory, Shiga University of Medical Science, Otsu, Shiga, Japan., Mizuno S; Laboratory Animal Resource Center in Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan. konezumi@md.tsukuba.ac.jp., Woltjen K; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan. woltjen@cira.kyoto-u.ac.jp., Ema M; Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science, Otsu, Shiga, Japan. mema@belle.shiga-med.ac.jp.; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, Japan. mema@belle.shiga-med.ac.jp. |
| Source: | Communications biology [Commun Biol] 2026 Mar 23; Vol. 9 (1). Date of Electronic Publication: 2026 Mar 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2399-3642 |
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| DOI: | 10.1038/s42003-026-09771-z |
