Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differences.

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Title: Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differences.
Authors: Wang N; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Yu G; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang Z; Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Alnobani A; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Jeevaratnam S; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Zhang X; Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., McReynolds M; Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Chang Y; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Qi F; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Tauer W; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Rosenberg C; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Wren M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Ikezu TC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Martens YA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Wang M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zhang B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Carter GW; The Jackson Laboratory, Bar Harbor, ME, USA., Sasner M; The Jackson Laboratory, Bar Harbor, ME, USA., Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA., Peng J; Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wu LJ; Department of Neurology, Mayo Clinic, Rochester, MN, USA.; Center for Neuroimmunology and Glial Biology, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA., Kanekiyo T; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. kanekiyo.takahisa@mayo.edu., Liu CC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. jenfttt13@gmail.com., Bu G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. gbu@ust.hk.; Division of Life Science and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. gbu@ust.hk.
Source: Molecular neurodegeneration [Mol Neurodegener] 2026 Mar 24; Vol. 21 (1). Date of Electronic Publication: 2026 Mar 24.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1750-1326
DOI:10.1186/s13024-026-00940-6