New series of pentamidine-based 1,2,3-triazole-diaryl-hydrazones: design, synthesis, and evaluation of their leishmanicidal activity and mechanism of action against Leishmania (L.) amazonensis.
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| Title: | New series of pentamidine-based 1,2,3-triazole-diaryl-hydrazones: design, synthesis, and evaluation of their leishmanicidal activity and mechanism of action against Leishmania (L.) amazonensis. |
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| Authors: | Espuri Sepini PF; Laboratory of Parasitology, Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG 37133-840 Brazil marcos.marques@unifal-mg.edu.br +55 (35) 3701 9576., Gontijo VS; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880., Tavares LM; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880., Souza LM; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880., Souza THF; Laboratory of Parasitology, Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG 37133-840 Brazil marcos.marques@unifal-mg.edu.br +55 (35) 3701 9576., Couto DS; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880., Nunes JB; Laboratory of Parasitology, Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG 37133-840 Brazil marcos.marques@unifal-mg.edu.br +55 (35) 3701 9576., Ribeiro CA; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto Porto Portugal., da Silva Cravo SMM; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto Porto Portugal., Zavan B; Laboratory for Antitumor Prototypes Evaluation, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG Brazil., Alves MA; Laboratory of Metabolomics - LabMeta/LADETEC, Federal University of Rio de Janeiro, Institute of Chemistry Rio de Janeiro RJ Brazil., Souza HMR; Laboratory of Metabolomics - LabMeta/LADETEC, Federal University of Rio de Janeiro, Institute of Chemistry Rio de Janeiro RJ Brazil., Ionta M; Laboratory of Metabolomics - LabMeta/LADETEC, Federal University of Rio de Janeiro, Institute of Chemistry Rio de Janeiro RJ Brazil., Sousa ME; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto Porto Portugal., Peloso EF; Department of Biochemistry, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG Brazil., Marques MJ; Laboratory of Parasitology, Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas Alfenas MG 37133-840 Brazil marcos.marques@unifal-mg.edu.br +55 (35) 3701 9576., Viegas C Jr; PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas Alfenas MG 37133-840 Brazil cvjviegas@gmail.com +55 (35) 3701 1880. |
| Source: | RSC medicinal chemistry [RSC Med Chem] 2026 Feb 27. Date of Electronic Publication: 2026 Feb 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem |
| Database: | MEDLINE Ultimate |
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