PD0325901 alleviates thrombin-inhibited osteogenic differentiation through an IL-1β-activated feedback loop between MEK-Erk1/2 and NF-κB signal pathways: insights from bioinformatics and experimental verification.
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| Title: | PD0325901 alleviates thrombin-inhibited osteogenic differentiation through an IL-1β-activated feedback loop between MEK-Erk1/2 and NF-κB signal pathways: insights from bioinformatics and experimental verification. |
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| Authors: | Ge YS; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Huang CM; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Shen J; Department of Orthopedic, Guanghua Hospital of Integrative Chinese and Western Medicine, Shanghai, China.; Arthritis Institute of Integrated Traditional Chinese and Western Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Meng TT; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Zhao MJ; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Yin JL; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Huang XH; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Chen LL; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Luo JH; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Zhai YQ; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Du JW; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.; Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China., Wang YL; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.; Department of Orthopedic, Guanghua Hospital of Integrative Chinese and Western Medicine, Shanghai, China., Wang XZ; Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China., Sun PP; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Ding DF; Department of Rehabilitation Therapy, The Second Rehabilitation Hospital of Shanghai, Shanghai, China.; Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. |
| Source: | Frontiers in immunology [Front Immunol] 2026 Mar 09; Vol. 17, pp. 1730337. Date of Electronic Publication: 2026 Mar 09 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2026.1730337 |
