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Toxicologic Pathology Forum: Opinion on Considerations for Determination of Adverse Versus Nonadverse Nerve Fiber Degeneration in Nonclinical Toxicity Studies of Oligonucleotides Delivered Directly Into the Intrathecal Space.

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Title: Toxicologic Pathology Forum: Opinion on Considerations for Determination of Adverse Versus Nonadverse Nerve Fiber Degeneration in Nonclinical Toxicity Studies of Oligonucleotides Delivered Directly Into the Intrathecal Space.
Authors: Berman-Booty LD; Ionis Pharmaceuticals, Carlsbad, California, USA., Pardo ID; Biogen, Inc., Cambridge, Massachusetts, USA., Bolon B; GEMpath, Inc., Longmont, Colorado, USA., Singh K; Wave Life Sciences, Cambridge, Massachusetts, USA., Morrison JP; Charles River Laboratories, Shrewsbury, Massachusetts, USA., Patrick S; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts, USA., Cramer S; StageBio, Frederick, Maryland, USA., Grieves JL; Ionis Pharmaceuticals, Carlsbad, California, USA.
Source: Toxicologic pathology [Toxicol Pathol] 2026 Jun; Vol. 54 (4), pp. 327-338. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: Sage Publications Country of Publication: United States NLM ID: 7905907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-1601 (Electronic) Linking ISSN: 01926233 NLM ISO Abbreviation: Toxicol Pathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Toxicologic Pathology Forum: Opinion on Considerations for Determination of Adverse Versus Nonadverse Nerve Fiber Degeneration in Nonclinical Toxicity Studies of Oligonucleotides Delivered Directly Into the Intrathecal Space.
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  Data: <searchLink fieldCode="AU" term="%22Berman-Booty+LD%22">Berman-Booty LD</searchLink>; Ionis Pharmaceuticals, Carlsbad, California, USA.<br /><searchLink fieldCode="AU" term="%22Pardo+ID%22">Pardo ID</searchLink>; Biogen, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Bolon+B%22">Bolon B</searchLink>; GEMpath, Inc., Longmont, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Singh+K%22">Singh K</searchLink>; Wave Life Sciences, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Morrison+JP%22">Morrison JP</searchLink>; Charles River Laboratories, Shrewsbury, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Patrick+S%22">Patrick S</searchLink>; Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Cramer+S%22">Cramer S</searchLink>; StageBio, Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Grieves+JL%22">Grieves JL</searchLink>; Ionis Pharmaceuticals, Carlsbad, California, USA.
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        Value: 10.1177/01926233261430687
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              Text: 2026 Jun
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