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Polypharmacology of S-1117, an Fc-fused IgG-selective degrading enzyme, for chronic treatment of autoantibody-mediated diseases.

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Bibliographic Details
Title: Polypharmacology of S-1117, an Fc-fused IgG-selective degrading enzyme, for chronic treatment of autoantibody-mediated diseases.
Authors: Sanmarco LM; Seismic Therapeutic, Watertown, MA 02472., Pellerin A; Seismic Therapeutic, Watertown, MA 02472., Green T; Seismic Therapeutic, Watertown, MA 02472., Plasencia A; Seismic Therapeutic, Watertown, MA 02472., Anderson JM; Seismic Therapeutic, Watertown, MA 02472., Le N; Seismic Therapeutic, Watertown, MA 02472., Newton A; Seismic Therapeutic, Watertown, MA 02472., Chen J; Independent Consultant, Moraga, CA 94556., Ramello MC; Seismic Therapeutic, Watertown, MA 02472., Peckner R; Seismic Therapeutic, Watertown, MA 02472., Manasson J; Seismic Therapeutic, Watertown, MA 02472., Xing Y; Seismic Therapeutic, Watertown, MA 02472., Vital H; Seismic Therapeutic, Watertown, MA 02472., Higginson-Scott N; Seismic Therapeutic, Watertown, MA 02472., Sundy JS; Seismic Therapeutic, Watertown, MA 02472., Otipoby KL; Seismic Therapeutic, Watertown, MA 02472., Mascanfroni ID; Seismic Therapeutic, Watertown, MA 02472.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Mar 31; Vol. 123 (13), pp. e2518366123. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2518366123