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Polypharmacology of S-1117, an Fc-fused IgG-selective degrading enzyme, for chronic treatment of autoantibody-mediated diseases.

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Title: Polypharmacology of S-1117, an Fc-fused IgG-selective degrading enzyme, for chronic treatment of autoantibody-mediated diseases.
Authors: Sanmarco LM; Seismic Therapeutic, Watertown, MA 02472., Pellerin A; Seismic Therapeutic, Watertown, MA 02472., Green T; Seismic Therapeutic, Watertown, MA 02472., Plasencia A; Seismic Therapeutic, Watertown, MA 02472., Anderson JM; Seismic Therapeutic, Watertown, MA 02472., Le N; Seismic Therapeutic, Watertown, MA 02472., Newton A; Seismic Therapeutic, Watertown, MA 02472., Chen J; Independent Consultant, Moraga, CA 94556., Ramello MC; Seismic Therapeutic, Watertown, MA 02472., Peckner R; Seismic Therapeutic, Watertown, MA 02472., Manasson J; Seismic Therapeutic, Watertown, MA 02472., Xing Y; Seismic Therapeutic, Watertown, MA 02472., Vital H; Seismic Therapeutic, Watertown, MA 02472., Higginson-Scott N; Seismic Therapeutic, Watertown, MA 02472., Sundy JS; Seismic Therapeutic, Watertown, MA 02472., Otipoby KL; Seismic Therapeutic, Watertown, MA 02472., Mascanfroni ID; Seismic Therapeutic, Watertown, MA 02472.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Mar 31; Vol. 123 (13), pp. e2518366123. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Polypharmacology of S-1117, an Fc-fused IgG-selective degrading enzyme, for chronic treatment of autoantibody-mediated diseases.
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  Data: <searchLink fieldCode="AU" term="%22Sanmarco+LM%22">Sanmarco LM</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Pellerin+A%22">Pellerin A</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Green+T%22">Green T</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Plasencia+A%22">Plasencia A</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Anderson+JM%22">Anderson JM</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Le+N%22">Le N</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Newton+A%22">Newton A</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Independent Consultant, Moraga, CA 94556.<br /><searchLink fieldCode="AU" term="%22Ramello+MC%22">Ramello MC</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Peckner+R%22">Peckner R</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Manasson+J%22">Manasson J</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Xing+Y%22">Xing Y</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Vital+H%22">Vital H</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Higginson-Scott+N%22">Higginson-Scott N</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Sundy+JS%22">Sundy JS</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Otipoby+KL%22">Otipoby KL</searchLink>; Seismic Therapeutic, Watertown, MA 02472.<br /><searchLink fieldCode="AU" term="%22Mascanfroni+ID%22">Mascanfroni ID</searchLink>; Seismic Therapeutic, Watertown, MA 02472.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Mar 31; Vol. 123 (13), pp. e2518366123. <i>Date of Electronic Publication: </i>2026 Mar 25.
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