CAFs-derived LAM332 promotes CTCs formation and survival via ITGA3 and contributes to the metastasis of pancreatic ductal adenocarcinoma.

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Title: CAFs-derived LAM332 promotes CTCs formation and survival via ITGA3 and contributes to the metastasis of pancreatic ductal adenocarcinoma.
Authors: Tang H; Department of Surgery, School of Medicine, Southeast University, Nanjing, Jiangsu, China., Shi W; Department of Surgery, School of Medicine, Southeast University, Nanjing, Jiangsu, China., Tan S; Department of Surgery, School of Medicine, Southeast University, Nanjing, Jiangsu, China., Zhang Z; Department of Surgery, School of Medicine, Southeast University, Nanjing, Jiangsu, China., Zhang Q; Department of Surgery, School of Medicine, Southeast University, Nanjing, Jiangsu, China., Zhou P; Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China., Wang Y; Department of Surgery, School of Medicine, Southeast University, Nanjing, Jiangsu, China.; Department of Hepato-Pancreatico-Biliary Surgery, Zhongda Hospital Southeast University, Nanjing, Jiangsu, China., Lei Z; Department of Surgery, School of Medicine, Southeast University, Nanjing, Jiangsu, China.; Department of Hepato-Pancreatico-Biliary Surgery, Zhongda Hospital Southeast University, Nanjing, Jiangsu, China., Hu F; Department of Surgery, School of Medicine, Southeast University, Nanjing, Jiangsu, China.; Department of Hepato-Pancreatico-Biliary Surgery, Zhongda Hospital Southeast University, Nanjing, Jiangsu, China., Gao S; Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Southeast University, Nanjing, China., Zhou J; Department of Surgery, School of Medicine, Southeast University, Nanjing, Jiangsu, China. zhoujh@seu.edu.cn.; Department of Hepato-Pancreatico-Biliary Surgery, Zhongda Hospital Southeast University, Nanjing, Jiangsu, China. zhoujh@seu.edu.cn.
Source: Cell death & disease [Cell Death Dis] 2026 Mar 25; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-026-08642-z