3D pentaculture model unveils malignant cell-driven macrophage polarization in high-grade serous ovarian cancer.

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Title: 3D pentaculture model unveils malignant cell-driven macrophage polarization in high-grade serous ovarian cancer.
Authors: Malacrida B; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Elorbany S; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Laforêts F; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Karim F; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK.; Department of Gynaecological Oncology Surgery, The Royal Marsden Hospital, London, UK., Bryan-Ravenscroft RC; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Sideris M; Wolfson Institute of Population Health, Queen Mary University of London, London, UK.; Department of Gynaecological Oncology, Barts Health NHS Trust, London, UK., Joy JD; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Kotantaki P; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Skingsley SLP; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Heath OM; Department of Gynaecological Oncology Surgery, The Royal Marsden Hospital, London, UK., Manchanda R; Wolfson Institute of Population Health, Queen Mary University of London, London, UK.; Department of Gynaecological Oncology, Barts Health NHS Trust, London, UK.; Department of Health Services Research, Faculty of Public Health & Policy, London School of Hygiene & Tropical Medicine, London, UK., Maniati E; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Balkwill FR; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK. f.balkwill@qmul.ac.uk.
Source: Nature communications [Nat Commun] 2026 Mar 25; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-70398-z