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3D pentaculture model unveils malignant cell-driven macrophage polarization in high-grade serous ovarian cancer.

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Title: 3D pentaculture model unveils malignant cell-driven macrophage polarization in high-grade serous ovarian cancer.
Authors: Malacrida B; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Elorbany S; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Laforêts F; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Karim F; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK.; Department of Gynaecological Oncology Surgery, The Royal Marsden Hospital, London, UK., Bryan-Ravenscroft RC; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Sideris M; Wolfson Institute of Population Health, Queen Mary University of London, London, UK.; Department of Gynaecological Oncology, Barts Health NHS Trust, London, UK., Joy JD; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Kotantaki P; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Skingsley SLP; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Heath OM; Department of Gynaecological Oncology Surgery, The Royal Marsden Hospital, London, UK., Manchanda R; Wolfson Institute of Population Health, Queen Mary University of London, London, UK.; Department of Gynaecological Oncology, Barts Health NHS Trust, London, UK.; Department of Health Services Research, Faculty of Public Health & Policy, London School of Hygiene & Tropical Medicine, London, UK., Maniati E; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Balkwill FR; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK. f.balkwill@qmul.ac.uk.
Source: Nature communications [Nat Commun] 2026 Mar 25; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Malacrida+B%22">Malacrida B</searchLink>; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Elorbany+S%22">Elorbany S</searchLink>; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Laforêts+F%22">Laforêts F</searchLink>; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Karim+F%22">Karim F</searchLink>; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK.; Department of Gynaecological Oncology Surgery, The Royal Marsden Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Bryan-Ravenscroft+RC%22">Bryan-Ravenscroft RC</searchLink>; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sideris+M%22">Sideris M</searchLink>; Wolfson Institute of Population Health, Queen Mary University of London, London, UK.; Department of Gynaecological Oncology, Barts Health NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Joy+JD%22">Joy JD</searchLink>; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kotantaki+P%22">Kotantaki P</searchLink>; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Skingsley+SLP%22">Skingsley SLP</searchLink>; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Heath+OM%22">Heath OM</searchLink>; Department of Gynaecological Oncology Surgery, The Royal Marsden Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Manchanda+R%22">Manchanda R</searchLink>; Wolfson Institute of Population Health, Queen Mary University of London, London, UK.; Department of Gynaecological Oncology, Barts Health NHS Trust, London, UK.; Department of Health Services Research, Faculty of Public Health & Policy, London School of Hygiene & Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Maniati+E%22">Maniati E</searchLink>; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Balkwill+FR%22">Balkwill FR</searchLink>; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK. f.balkwill@qmul.ac.uk.
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