Non-telomeric function deficiency of TERT enhances pressure overload-induced mouse cardiac remodeling by activation of CNBP-mediated THBS3/ITGB1 pathway.

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Bibliographic Details
Title: Non-telomeric function deficiency of TERT enhances pressure overload-induced mouse cardiac remodeling by activation of CNBP-mediated THBS3/ITGB1 pathway.
Authors: Liu YY; Basic Laboratory of Cardiovascular Disease, Institute of Translational Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China., Wang YC; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310020, China., Gong WY; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China., Luo H; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China., Yuan JH; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China., Chen Z; Basic Laboratory of Cardiovascular Disease, Institute of Translational Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China., Xu XL; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China., Yang J; Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 31112, China., Cong YS; Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 31112, China., Zhang XW; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China.; Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China., Jiao QB; Basic Laboratory of Cardiovascular Disease, Institute of Translational Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China. 20130012@hznu.edu.cn.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China. 20130012@hznu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Aug; Vol. 47 (8), pp. 2112-2129. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1745-7254
DOI:10.1038/s41401-026-01750-8