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Non-telomeric function deficiency of TERT enhances pressure overload-induced mouse cardiac remodeling by activation of CNBP-mediated THBS3/ITGB1 pathway.

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Title: Non-telomeric function deficiency of TERT enhances pressure overload-induced mouse cardiac remodeling by activation of CNBP-mediated THBS3/ITGB1 pathway.
Authors: Liu YY; Basic Laboratory of Cardiovascular Disease, Institute of Translational Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China., Wang YC; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310020, China., Gong WY; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China., Luo H; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China., Yuan JH; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China., Chen Z; Basic Laboratory of Cardiovascular Disease, Institute of Translational Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China., Xu XL; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China., Yang J; Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 31112, China., Cong YS; Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 31112, China., Zhang XW; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China.; Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China., Jiao QB; Basic Laboratory of Cardiovascular Disease, Institute of Translational Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China. 20130012@hznu.edu.cn.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China. 20130012@hznu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Aug; Vol. 47 (8), pp. 2112-2129. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Non-telomeric function deficiency of TERT enhances pressure overload-induced mouse cardiac remodeling by activation of CNBP-mediated THBS3/ITGB1 pathway.
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  Data: <searchLink fieldCode="AU" term="%22Liu+YY%22">Liu YY</searchLink>; Basic Laboratory of Cardiovascular Disease, Institute of Translational Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.<br /><searchLink fieldCode="AU" term="%22Wang+YC%22">Wang YC</searchLink>; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310020, China.<br /><searchLink fieldCode="AU" term="%22Gong+WY%22">Gong WY</searchLink>; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China.<br /><searchLink fieldCode="AU" term="%22Luo+H%22">Luo H</searchLink>; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China.<br /><searchLink fieldCode="AU" term="%22Yuan+JH%22">Yuan JH</searchLink>; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Basic Laboratory of Cardiovascular Disease, Institute of Translational Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.<br /><searchLink fieldCode="AU" term="%22Xu+XL%22">Xu XL</searchLink>; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 31112, China.<br /><searchLink fieldCode="AU" term="%22Cong+YS%22">Cong YS</searchLink>; Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 31112, China.<br /><searchLink fieldCode="AU" term="%22Zhang+XW%22">Zhang XW</searchLink>; Hangzhou Institute of Cardiovascular Disease, Hangzhou, 310015, China.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China.; Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.<br /><searchLink fieldCode="AU" term="%22Jiao+QB%22">Jiao QB</searchLink>; Basic Laboratory of Cardiovascular Disease, Institute of Translational Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China. 20130012@hznu.edu.cn.; Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China. 20130012@hznu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2026 Aug; Vol. 47 (8), pp. 2112-2129. <i>Date of Electronic Publication: </i>2026 Mar 25.
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              Text: 2026 Aug
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