CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma.
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| Title: | CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma. |
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| Authors: | Lier S; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Markusson SB; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Kocijancic A; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway., Narum M; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Lund SO; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Böllering B; Institute of Neuropathology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Lipsa A; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg., Søegaard MLC; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway.; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Rein ID; Department of Core Facilities, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway., Santha P; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Jain P; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Lång A; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Lång E; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Meyer N; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Dutta A; National Institute of technology, Silchar, India., Anand S; Division of Biological Sciences, University of Missouri, Columbia, 65211, MO, USA., Badugu SB; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Nesse GJ; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Forstrøm RJ; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Klungland A; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Anand A; Department of Computer Science and Engineering, Indian Institute of Technology, Guwahati, Assam, India., Pollard SM; Institute for Regeneration and Repair & Cancer Research UK Scotland Centre, Edinburgh, United Kingdom., Bøe SO; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Rinholm JE; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Frauenknecht KBM; Institute of Neuropathology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.; National Center of Pathology, Laboratoire national de santé, Dudelange, Luxembourg., Golebiewska A; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg., Niclou SP; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg.; Department of Life Sciences and Medicine, University of Luxembourg, Belval, Luxembourg., Somyajit K; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Lerdrup M; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway. mlerdrup@sund.ku.dk.; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark. mlerdrup@sund.ku.dk., Pandey DP; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway. deopan@ous-hf.no.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway. deopan@ous-hf.no. |
| Source: | EMBO molecular medicine [EMBO Mol Med] 2026 May; Vol. 18 (5), pp. 1592-1624. Date of Electronic Publication: 2026 Mar 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1757-4684 |
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| DOI: | 10.1038/s44321-026-00393-w |
