View in EDS HTML Full Text PDF Full Text

CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma.

Saved in:
Bibliographic Details
Title: CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma.
Authors: Lier S; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Markusson SB; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Kocijancic A; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway., Narum M; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Lund SO; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Böllering B; Institute of Neuropathology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Lipsa A; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg., Søegaard MLC; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway.; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Rein ID; Department of Core Facilities, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway., Santha P; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Jain P; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Lång A; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Lång E; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Meyer N; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Dutta A; National Institute of technology, Silchar, India., Anand S; Division of Biological Sciences, University of Missouri, Columbia, 65211, MO, USA., Badugu SB; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Nesse GJ; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Forstrøm RJ; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Klungland A; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Anand A; Department of Computer Science and Engineering, Indian Institute of Technology, Guwahati, Assam, India., Pollard SM; Institute for Regeneration and Repair & Cancer Research UK Scotland Centre, Edinburgh, United Kingdom., Bøe SO; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway., Rinholm JE; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Frauenknecht KBM; Institute of Neuropathology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.; National Center of Pathology, Laboratoire national de santé, Dudelange, Luxembourg., Golebiewska A; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg., Niclou SP; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg.; Department of Life Sciences and Medicine, University of Luxembourg, Belval, Luxembourg., Somyajit K; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Lerdrup M; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway. mlerdrup@sund.ku.dk.; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark. mlerdrup@sund.ku.dk., Pandey DP; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway. deopan@ous-hf.no.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway. deopan@ous-hf.no.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 May; Vol. 18 (5), pp. 1592-1624. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41882177
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Lier+S%22">Lier S</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Markusson+SB%22">Markusson SB</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Kocijancic+A%22">Kocijancic A</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Narum+M%22">Narum M</searchLink>; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Lund+SO%22">Lund SO</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Böllering+B%22">Böllering B</searchLink>; Institute of Neuropathology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Lipsa+A%22">Lipsa A</searchLink>; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Søegaard+MLC%22">Søegaard MLC</searchLink>; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway.; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Rein+ID%22">Rein ID</searchLink>; Department of Core Facilities, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Santha+P%22">Santha P</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Jain+P%22">Jain P</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Lång+A%22">Lång A</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Lång+E%22">Lång E</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Meyer+N%22">Meyer N</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Dutta+A%22">Dutta A</searchLink>; National Institute of technology, Silchar, India.<br /><searchLink fieldCode="AU" term="%22Anand+S%22">Anand S</searchLink>; Division of Biological Sciences, University of Missouri, Columbia, 65211, MO, USA.<br /><searchLink fieldCode="AU" term="%22Badugu+SB%22">Badugu SB</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Nesse+GJ%22">Nesse GJ</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Forstrøm+RJ%22">Forstrøm RJ</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Klungland+A%22">Klungland A</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Anand+A%22">Anand A</searchLink>; Department of Computer Science and Engineering, Indian Institute of Technology, Guwahati, Assam, India.<br /><searchLink fieldCode="AU" term="%22Pollard+SM%22">Pollard SM</searchLink>; Institute for Regeneration and Repair & Cancer Research UK Scotland Centre, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bøe+SO%22">Bøe SO</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Rinholm+JE%22">Rinholm JE</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.; Institute of Basic Medical Sciences and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Frauenknecht+KBM%22">Frauenknecht KBM</searchLink>; Institute of Neuropathology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.; National Center of Pathology, Laboratoire national de santé, Dudelange, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Golebiewska+A%22">Golebiewska A</searchLink>; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Niclou+SP%22">Niclou SP</searchLink>; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg.; Department of Life Sciences and Medicine, University of Luxembourg, Belval, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Somyajit+K%22">Somyajit K</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Lerdrup+M%22">Lerdrup M</searchLink>; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway. mlerdrup@sund.ku.dk.; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark. mlerdrup@sund.ku.dk.<br /><searchLink fieldCode="AU" term="%22Pandey+DP%22">Pandey DP</searchLink>; Department of Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway. deopan@ous-hf.no.; CRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway. deopan@ous-hf.no.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101487380%22">EMBO molecular medicine</searchLink> [EMBO Mol Med] 2026 May; Vol. 18 (5), pp. 1592-1624. <i>Date of Electronic Publication: </i>2026 Mar 25.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22EMBO+Press%22">EMBO Press </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101487380 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-4684 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217574676%22">17574676 </searchLink><i>NLM ISO Abbreviation: </i>EMBO Mol Med <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41882177
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s44321-026-00393-w
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1592
    Titles:
      – TitleFull: CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Lier S
      – PersonEntity:
          Name:
            NameFull: Markusson SB
      – PersonEntity:
          Name:
            NameFull: Kocijancic A
      – PersonEntity:
          Name:
            NameFull: Narum M
      – PersonEntity:
          Name:
            NameFull: Lund SO
      – PersonEntity:
          Name:
            NameFull: Böllering B
      – PersonEntity:
          Name:
            NameFull: Lipsa A
      – PersonEntity:
          Name:
            NameFull: Søegaard MLC
      – PersonEntity:
          Name:
            NameFull: Rein ID
      – PersonEntity:
          Name:
            NameFull: Santha P
      – PersonEntity:
          Name:
            NameFull: Jain P
      – PersonEntity:
          Name:
            NameFull: Lång A
      – PersonEntity:
          Name:
            NameFull: Lång E
      – PersonEntity:
          Name:
            NameFull: Meyer N
      – PersonEntity:
          Name:
            NameFull: Dutta A
      – PersonEntity:
          Name:
            NameFull: Anand S
      – PersonEntity:
          Name:
            NameFull: Badugu SB
      – PersonEntity:
          Name:
            NameFull: Nesse GJ
      – PersonEntity:
          Name:
            NameFull: Forstrøm RJ
      – PersonEntity:
          Name:
            NameFull: Klungland A
      – PersonEntity:
          Name:
            NameFull: Anand A
      – PersonEntity:
          Name:
            NameFull: Pollard SM
      – PersonEntity:
          Name:
            NameFull: Bøe SO
      – PersonEntity:
          Name:
            NameFull: Rinholm JE
      – PersonEntity:
          Name:
            NameFull: Frauenknecht KBM
      – PersonEntity:
          Name:
            NameFull: Golebiewska A
      – PersonEntity:
          Name:
            NameFull: Niclou SP
      – PersonEntity:
          Name:
            NameFull: Somyajit K
      – PersonEntity:
          Name:
            NameFull: Lerdrup M
      – PersonEntity:
          Name:
            NameFull: Pandey DP
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: 2026 May
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1757-4684
          Numbering:
            – Type: volume
              Value: 18
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: EMBO molecular medicine
              Type: main
ResultId 1